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ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158
The Association of A−1082→G Polymorphism of IL-10 and (A−308→G) Polymorphism of TNFα Genes with Bone Density in Elderly Women
Краткое описание
We studied the association between bone mineral density and (A −1082→G) polymorphism of IL-10 and (A−308→G) polymorphism of TNFα genes. SNP-polymerase chain reaction was used. The study failed to find significant association of A−308→G TNFα polymorphism and bone state in postmenopausal women. The patients with AA genotype of A−1082→G IL-10 gene have significantly lower indices of bone mineral density comparing with G allele carriers (GG/AG). This association remained true for data of bone mineral density of total body, and separate parts of skeleton: lumbar spine, femoral neck, Ward's triangle of total femur. Our study indicates that A−308→G polymorphism of TNFα gene is not associated with indices of bone mineral density in postmenopausal women. However, there is strong evidence that women, carriers of AA genotype of A−1082→G polymorphism of IL-10 gene have significantly lower indices of bone mineral density. This indicates the potential for predictive genetic testing of osteoporosis risk. Analyses of gene combination IL-10 G−1082→G and TNFα G−308→G ('antiinflammatory genotype') did not show any significant association of this genotype with bone characteristics, which shows low predictive value of this combination for diagnostics of osteoporosis.