Доступ предоставлен для: Guest
International Journal of Physiology and Pathophysiology
Главный редактор: Vadim F. Sagach (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 2155-014X

ISSN Онлайн: 2155-0158

SJR: 0.116

Changes in the Brain Testosterone Metabolism and Sexual Behavior of Male Rats Prenatally Exposed to Methyldopa and Stress

Том 7, Выпуск 3, 2016, pp. 231-238
DOI: 10.1615/IntJPhysPathophys.v7.i3.50
Get accessGet access

Краткое описание

The changes in aromatase and 5α-reductase activities in the preoptic area (POA) and the medial basal hypothalamus of 10-day-old male rats, and sexual behavior of 3-month- old male rats, offsprings of females exposed to noradrenaline antagonist methyldopa (400 mg/kg per os) 30 minutes prior to 1-hour immobilization during the last week of pregnancy (daily, from 15th to 21st day) were studied. Prenatal stress caused aromatase activity lowering in the POA of developing brain and feminization (appearance of lordosis) and demasculinization of sexual behavior (prolongation of latent periods to the first mounting and first intromission) in young male offspring. Oral methyldopa used prior to stressing of pregnant females prevented early effect of prenatal stress on aromatase activity in the POA and some disorders of the male sexual behavior in young male rats. The data obtained indicate that brain noradrenergic system plays significant role in the mechanisms of metabolic and behavioral disturbances developing in male rats exposed to prenatal stress.

777 Просмотры статей 2 Загрузка статей Метрики
777 ПРОСМОТРЫ 2 ЗАГРУЗКИ Google
Scholar
ЦИТАТЫ

Статьи с похожим содержанием:

Modulation of Puberty Terms and Sexual Behavior of Rats after Prenatal Exposure to Methyldopa, Phenibut, and Stress International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 1
Anna A. Limareva, Alexander G. Reznikov
Effects of N-Stearoylethanolamine on the Emotionality and Learning Ability of Rats International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 4
N. M. Hula, T. M. Horid'ko, O. A. Kovalenko, Oleksandr V. Bondarenko, Mykola Yu. Makarchuk
Protective Effects of Picorrhiza Kurroa Extract against 2-Acetylaminofluorene-Induced Hepatotoxicity in Wistar Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 3
Sarwat Sultana, Sahar Rahman
Aphrodisiac Activity of an Aqueous Extract of Wood Ear Mushroom, Auricularia polytricha (Heterobasidiomycetes), in Male Rats International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 1
Gaurav Gupta, Sanjay Sharma, Ganesh N. Sharma, Rakesh Kumar Sharma, Kamal Dua, Rajiv Dahiya, Juhi Tiwari, Anurag Mishra
Hypersexual Behavior and Hyperandrogenism in F1 Male Rats Caused by Dibutyl Phthalate Treatment of Pregnant Females International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 3
Olga V. Sachynska, Anna A. Limareva, Oksana A. Faliush, Alexander G. Reznikov, Inna G. Perchik

Последний выпуск

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain