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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v7.i2.60
pages 149-155

The Effect of Exogenous Melatonin on Bone Remodeling

Vadim A. Berezovskiy
Bogomolets Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
Irina G. Litovka
Bogomolets Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
Stanislav P. Veselsky
Kyiv National Taras Shevchenko University, Kyiv, Ukraine
Roman V. Janko
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Uliana O. Zhernoklov
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Краткое описание

We studied the effects of pharmacological doses of melatonin (5 mg / kg) introduced in springtime during 28 days on parameters of bone remodeling in 3-month old male rats with high and low levels of energy metabolism. Decreased activity of osteoblasts and increased osteoclast activity, independent from intensity of energy metabolism, have been shown, as well as increased concentration of glycosaminoglycans and free amino acids, testifying to the inhibition of bone tissue physiological remodeling. The latter is not beneficial in maintaining integrity of the bone organic matrix and fixing the inorganic component of the connective tissue, namely hydroxyapatite crystals.

Ключевые слова: melatonin, bone tissue

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