Краткое описание

We studied the effect of 1% sodium hydrosulfide solution (NaHS) on intraocular pressure (IOP) in intact rats and those with simulated ocular hypertension induced by prolonged systemic administration of adrenaline. A single administration of hydrogen sulfide donor as drops into the eye cavity caused the hypotensive effect, which was rather weak in the eyes of intact rats and pronounced in those with ocular hypertension. Long-term administration of NaHS by the scheme, against the background of applying adrenaline as inductor, to a large extent, prevented the IOP rise. It has been concluded that hydrogen sulfide is involved in the regulation of intraocular hydrodynamics and maintaining normal IOP levels.