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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v8.i4.70
pages 347-353

Single-Channel Ion Currents in the Nuclear Envelope of Rat Cardiomyocytes

O. A. Kotyk
Bogomolets Institute of Physiology, NASU, Kyiv, Ukraine
Anna B. Kotliarova
Bogomolets Institute of Physiology, NASU, Kyiv, Ukraine
A. O. Polishchuk
Bogomolets Institute of Physiology, NASU, Kyiv, Ukraine
Sergey M. Marchenko
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv

Краткое описание

Using the patch clamp technique in nucleus attached configuration, we have found that the nuclear membrane of rat cardiomyocytes contains different types of ion channels with conductances in the range from 10 to 400 pSm. In particular, we recorded inositol 1,4,5-trisphosphate receptors with conductance of (384 ± 5) pS, as well as cation channels with conductance of (209 ± 13) pS which are similar to large-conductance (LCC)-channels, previously reported in neurons. In addition, we have found at least two types of ion channels with significantly higher conductance than that of LCC-channels, and several types of ion channels with lower conductance (10 – 90 pSm).


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