Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
In Silico Analysis of Lanostanoids Characterized in Ganoderma Mushrooms (Agaricomycetes) as Potential Ligands of the Vitamin D Receptor
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Краткое описание
The metabolism of vitamin D is a very important pathway involved in the regulation of sterols and maintenance of cell health. The physiological activity of the human hormone 1α,25-dihydroxyvitamin D3, or calcitriol, is mediated by the vitamin D receptor (VDR), an endocrine member of the nuclear receptor superfamily that inhibits cell growth and stimulates cell differentiation, suggesting a potential application in cancer chemoprevention. Since nonpolar extracts obtained from Ganoderma mushrooms have also been shown to exert an antiproliferative effect on several cancer cell lines, it was suggested that at least part of its activity might be mediated by VDR. The aim of this work was to identify possible VDR ligands from an extensive library of lanostanoids isolated from several Ganoderma mushrooms. Using an in silico approach, 30 lanostanoids were found to interact with the VDR ligand-binding pocket in the same way as calcitriol. The possible implications of using these compounds are discussed here.
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Wang Jian, Li Wei, Wang Bo, Hu Baichun, Jiang Hailun, Lai Bate, Li Ning, Cheng Maosheng, In Silicon Approach for Discovery of Chemopreventive Agents, Current Pharmacology Reports, 3, 4, 2017. Crossref
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Xu Hui, Wang Yuchen, Zhao Junnan, Jurutka Peter W., Huang Dechun, Liu Liangyun, Zhang Lange, Wang Suilou, Chen Yadong, Cheng Shujie, Triterpenes from Poria cocos are revealed as potential retinoid X receptor selective agonists based on cell and in silico evidence , Chemical Biology & Drug Design, 95, 5, 2020. Crossref