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International Journal of Medicinal Mushrooms
Главный редактор: Solomon P. Wasser (open in a new tab)

Выходит 12 номеров в год

ISSN Печать: 1521-9437

ISSN Онлайн: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Screening Antitumor Activity of Low-Molecular-Weight Compounds Obtained from the Fruit Bodies of Family Agaricaceae Chevall. (Higher Basidiomycetes)

Том 7, Выпуск 3, 2005, pp. 398-400
DOI: 10.1615/IntJMedMushrooms.v7.i3.450
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Краткое описание

Numerous higher Basidiomycetes are an important source of medicinal substances, applied in the treatment of a wide range of ailments. The anticancer activity of mushroom-derived components has long been known and is well documented. The majority of active substances are high-molecular-weight (HMW) (200–400,000 Da) polysaccharides and polysaccharide complexes, active hexose correlated compounds (AHCC), polysaccharide-peptides, nucleosides, triterpenoids, complex starches, and other metabolites. Of the known 918 Agaricaceae species (Kirk et al., 2001), only 37 species of eight genera were screened on HMW antitumor active compounds (Ohta et al., 1999), and three species (Agaricus langei (F.H. Moller et Jul. Schaff .) Maire, Leucoagaricus carneifolius (Gillet) S. Wasser, L. leucothites (Vittad.) M.M. Moser ex Bon), were screened for low-molecular-weight (LMW) antitumor-active substances (Yassin et al., 2003). While activity of HMW substances is attributed to the immunemodulating function, LMW substances might show a direct antitumor eff ect against cancer cells.
The current study examined the anticancer activity of extracts, obtained using different organic solvents (dichloromethane: DCHM, ethyl acetate: EtAc, and methanol: Meth). Overall, 13 species (eight Agaricus, three Macrolepiota, one Leucoagaricus, and one Lepiota) were screened. Six lines of three types of cancer were studied: prostate cancer cell lines LNCaP (androgen-dependent prostate cancer; the cell line carries mutation T877A in the androgen receptor); DU145; PC3 (both lines androgen-independent); breast cancer cell line MDA-kb2 (MDAMB-453); patient-derived chronic myelogeneous leukemia cell (CML) lines (K562); and laboratory model of CML, Baf 3/p185 Bcr-Abl. All cell lines were subjected to 36 extracts, each of which was tested in two concentrations. When setting up the experiment, attention was focused on extracts able to inhibit nonselectively all cell lines used, as well as extracts that would inhibit growth of a specific type of cancer selectively.

ЦИТИРОВАНО В
  1. Cheong Peter Chiew Hing, Tan Chon Seng, Fung Shin Yee, Application of Wild Macrofungi as Anticancer Therapeutics, in Biology of Macrofungi, 2018. Crossref

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