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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v7.i3.650
423 pages

The Receptor for β-Glucan of Ganoderma lucidum (W.Curt.:Fr.) Lloyd in Immune Cells

Ha Won Kim
Department of Life Sciences, University of Seoul Dongdaemun-gu, Jennong-dong 90, Seoul 130-743, South Korea
Byong Kak Kim
College of Pharmacy Seoul National University Seoul 151-724; and Department of Life Science, University of Seoul, Seoul 130-743, South Korea

Краткое описание

The mechanisms on how polysaccharides of medicinal mushrooms can be absorbed and used in the potentiation of immunity in human bodies has not been elucidated until recently. In 2001, dectin-1 was identified as a β-glucan receptor, which is calcium dependent and whose gene is located on mouse chromosome 6 and human chromosome 12. The dectin-1 mRNA is highly expressed in dendritic cells. Dendritic cells and macrophages have pattern recognition molecules for binding β-glucan. Dectin-1 was also found in murine organs, spleen, thymus, lung, and intestines. Treatment of macrophages with β-glucan of Ganoderma lucidum (GLG) resulted in an increase of IL-6 and TNF-α in the presence of LPS. But GLG alone did not increase IL-6 or TNF-α. The results suggest that dectin-1 may cooperate with CD-14 to activate signal transduction, which is important in immune responses.


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