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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v9.i1.20
pages 7-14

Evaluation of Therapeutic Activity of Hypogeous Ascomycetes and Basidiomycetes from North America

Rita Stanikunaite
Department of Pharmacognosy, The University of Mississippi, University, MS, USA
James M. Trappe
Department of Forest Service, Oregon State University, Corvallis, Oregon 97331-5257, USA
Shabana I. Khan
National Center for Natural Products Research, The University of Mississippi, University, MS, USA
Samir A. Ross
Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677

Краткое описание

This study is the first broad investigation of therapeutic activities of hypogeous truffles and truffle-like fungi (Ascomycetes and Basidiomycetes) from North America. Twenty-two species from 12 families were evaluated in several biological assays for antimicrobial, antimalarial, antiinflammatory, antioxidant, antituberculosis, and anticancer activities. Biological screening results indicate that 1 species showed antimalarial activity, 11 species were active in antioxidant assay, 9 species were active in antiinflammatory assay, 9 species showed antituberculosis activity, and 2 species showed anticancer activity. Among the screened species, Elaphomyces granulatus, E. muricatus, Geopora clausa, Hymenogaster subalpinus, Melanogaster tuberiformis, Rhizopogon couchii, R. nigrescens, R. pedicellus, R. subaustralis, R. subgelatinosus, and Scleroderma laeve expressed therapeutic activity in more than one assay. Our results indicate that this group of fungi has promising therapeutic activities that could lead to the development of new agents for the treatment and prevention of diseases.


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