Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i5.70
pages 471-479

Medicinal Mushroom Extracts Possess Differential Antioxidant Activity and Cytotoxicity to Cancer Cells

Eman Nasr Elbatrawy
Regional Center for Mycology and Biotechnology, Al Azhar University, Cairo, Egypt; Department of Biology, Virginia Commonwealth University, Richmond, VA, USA
Eglal AbdAllah Ghonimy
Department of Botany, Faculty of Science, Al Azhar University, Cairo, Egypt
Mahomud Mohammed Alassar
Regional Center for Mycology and Biotechnology, Al Azhar University, Cairo, Egypt
Fang-Sheng Wu
Department of Biology, Virginia Commonwealth University, Richmond, VA, USA

Краткое описание

Many species of edible mushrooms are known to contain a wide array of compounds with high nutritional and medicinal values. However, these values vary widely among mushroom species because of the wide diversity of compounds with different solubilities to solvents used in extraction. We report here the comparison of antioxidant activity and cytotoxicity against cancer cells in extracts of Pleurotus ostreatus, P. sajor-caju, Agaricus campestris, and A. bisporus from 7 different solvents, including water, ethanol, ethyl acetate, acetone, chloroform, hexane, and petroleum ether. The extracts were analyzed for their antioxidant activities using the % DPPH (2,2-diphenyl-1-picrylhydrazylhydrate) scavenging activity method. Our results revealed that the water extracts exhibited the highest % DPPH scavenging activity in comparison to all other solvent extracts. The highest value was obtained from the water extract of P. sajor-caju (78.1%), and the lowest one was from the hexane extract of A. bisporus (0.8%). In general, extracts from nonpolar solvents exhibited much lower antioxidant activities than those from polar solvents. The cytotoxic effects of these extracts were evaluated using 2 cancer cell lines of larynx carcinoma (HEp-2) and breast carcinoma (MCF-7). When added into Hep-2 cells, the hexane extracts from P. ostreatus, P. sajor-caju, A. bisporus, and A. campestris yielded the highest IC50 values of 1.7 ± 1.56, 2.1 ± 2.82, 4.4 ± 1.71, and 2.2 ± 1.34 μg/mL, respectively, in comparison to all other solvent extracts. Similar IC50 values were obtained when the MCF-2 cancer cells were tested, suggesting that hexane is the preferred solvent to extract the anticancer compounds from these mushrooms. Our results also indicated that extracts from solvents with nonpolar or intermediate polarity were more potent than those with high polarity in their cytotoxicity against cancer cells, and extracts from different mushrooms by the same solvent possessed varied degrees of cytotoxicity.


Articles with similar content:

Identification and Evaluation of Bioactivity of Compounds from the Mushroom Pleurotus nebrodensis (Agaricomycetes) against Breast Cancer
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 9
Xueya Zhang, Xiaohong Kou, Wancong Yu, Ru Wang, Zhaohui Xue, Jingfeng Hao
Antioxidant Capacity and Total Phenolics Content of the Fruiting Bodies and Submerged Cultured Mycelia of Sixteen Higher Basidiomycetes Mushrooms from India
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 10
Rajendra Prasad, N. S. K. Harsh, Vinay K. Varshney, Manoj Kumar
Chemical Composition and Antioxidant and Antibacterial Activities of Cultured Mycelia of Four Clavicipitaceous Mushrooms (Ascomycetes) from the Indian Himalayas
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 1
Nandini Gautam, Sapan Kumar Sharma
Growth-Inhibitory and Immunomodulatory Activities of Wild Mushrooms from North-Central British Columbia (Canada)
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 6
Chow H. Lee, Vicky Myhre, Aaron Smith, Sumreen Javed, Linda E. Tackaberry, Ankush Barad, Keith N. Egger, Kerry Reimer, Hugues B. Massicotte, Wai Ming Li, Geoffrey W. Payne
Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Inhibits Candida Biofilms: A Metabolomic Approach
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 8
Kshipra Misra, Ajai Kumar, Jigni Mishra, Payal Gupta, Navin Kumar, Anuja Bhardwaj, Rakhee