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International Journal of Medicinal Mushrooms
Главный редактор: Solomon P. Wasser (open in a new tab)

Выходит 12 номеров в год

ISSN Печать: 1521-9437

ISSN Онлайн: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Immune Responses to Water-Soluble Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) P. Karst. Polysaccharides in Patients with Advanced Colorectal Cancer

Том 7, Выпуск 4, 2005, pp. 525-538
DOI: 10.1615/IntJMedMushr.v7.i4.20
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Краткое описание

Preclinical studies have established that the polysaccharide fractions of Ganoderma lucidum have potent immunomodulating effects. A recent clinical study of healthy volunteers demonstrated that G. lucidum did not affect their immune functions. The present open-labeled study aimed to evaluate the effects of water-soluble G. lucidum polysaccharides (Ganopoly) in patients with advanced colorectal cancer. Forty-seven patients were enrolled and treated with Ganopoly at 5.4 g/day for 12 weeks. In 41 assessable cancer patients, treatment with Ganopoly tended to increase mitogenic reactivity to phytohemagglutinin; counts of CD3, CD4, CD8, and CD56; plasma concentrations of interleukin (IL)-2, IL-6, and interferon (IFN)-γ; and NK activity, but to decrease the plasma concentrations of IL-1 and tumor necrosis factor (TNF)-α. No statistical significance was observed when a comparison was conducted between baseline values and those after 12-week treatment with Ganopoly. The changes of IL-1 were correlated with those of IL-6, IFN-γ, CD3, CD4, CD8, and NK activity (p < 0.05), and IL-2 changes were correlated with those for IL-6, CD8, and NK activity. The results indicate that Ganopoly may have beneficial immunomodulating effects in patients with advanced colorectal cancer. Further studies are needed to explore the mode of action, efficacy, and safety of Ganopoly in cancer patients.

ЦИТИРОВАНО В
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