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International Journal of Medicinal Mushrooms
Главный редактор: Solomon P. Wasser (open in a new tab)

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ISSN Печать: 1521-9437

ISSN Онлайн: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Immunomodulation Activity of a Polysaccharide Fraction of a Culinary-Medicinal Mushroom, Pleurotus citrinopileatus Singer (Agaricomycetideae), in Vitro

Том 10, Выпуск 3, 2008, pp. 235-244
DOI: 10.1615/IntJMedMushr.v10.i3.40
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Краткое описание

The hot water soluble extract of Pleurotus citrinopileatus (HWE-P) induced high expression of mRNA of tumor necrosis factor (TNF)-α, which is a proinflammatory cytokine, in the stimulated murine macrophage RAW264. However, unlike lipopolysaccharides (LPS), the extract did not induce the expression of mRNA in other cytokines, such as in IL-12 and IL-10. TNF-α production, which was induced from RAW264 stimulated with HWE-P (1 mg·mL−1), was approximately 400 pg·mL−1. These findings showed that the fruiting body of P. citrinopileatus stimulated an early immunological response of a murine macrophage. Furthermore, we chromatographically separated and purified an active fraction from the crude extract of P. citrinopileatus and measured its immunomodulating activity in cytokine production from the stimulated macrophages. This crude extract was separated into six fractions (HWE-P-I, II, III, IV, V, and VI) by anion exchange chromatography using DEAE-Sepharose gel. Then it was found that the HWE-P-IV fraction, which possessed a molecular mass approximately 450 kDa, showed the strongest immunomodulating activity in TNF-α production (4.9 ng·mL−1) from the macrophages. This fraction was mainly composed of a sugar. Moreover, production of nitric oxide (NO) was detected in the macrophages stimulated with this fraction. The amount of NO produced from stimulated RAW264 was 33.8 μM. These results indicate that a polysaccharide fraction from P. citrinopileatus possesses a potent immunomodulating activity. Thus, this culinary-medicinal species could become an effective component of a functional food.

ЦИТИРОВАНО В
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  3. Jo Eun-Kyung, Heo Da-Jung, Kim Jeong-Han, Lee Yun-Hae, Ju Young-Cheoul, Lee Seung-Cheol, The Effects of Subcritical Water Treatment on Antioxidant Activity of Golden Oyster Mushroom, Food and Bioprocess Technology, 6, 9, 2013. Crossref

  4. Minato Ken-ichiro, Laan Lisa C., Ohara Akihiro, van Die Irma, Pleurotus citrinopileatus polysaccharide induces activation of human dendritic cells through multiple pathways, International Immunopharmacology, 40, 2016. Crossref

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  6. Minato Ken-ichiro, Laan Lisa C., van Die Irma, Mizuno Masashi, Pleurotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation, International Journal of Biological Macromolecules, 122, 2019. Crossref

  7. Brito Dayane R., Carbonero Elaine R., Viana Sthefany R.F., Silva Estefânia V., Ruthes Andrea Caroline, Lião Luciano M., Iacomini Marcello, Partially methylated galactans containing different proportions of 3-O-methyl-galactose from Pleurotus citrinopileatus, Carbohydrate Research, 458-459, 2018. Crossref

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