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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i6.10
pages 469-476

Antimicrobial and Cytotoxic Activities of the Sulphur Shelf Medicinal Mushroom, Laetiporus sulphureus (Agaricomycetes), from Serbia

Marina D. Kolundzic
Faculty of Pharmacy, Department of Pharmacognosy, University of Belgrade, Belgrade, Serbia
Nada O. Grozdanic
Institute for Oncology and Radiology of Serbia, Belgrade, Serbia
Tatjana P. Stanojkovic
Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
Marina T. Milenkovic
Faculty of Pharmacy, Department of Immunology and Microbiology, University of Belgrade, Belgrade, Serbia
Miroslav R. Dinic
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
Natasa E. Golic
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
Milan Kojic
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
Tatjana D. Kundakovic
Faculty of Pharmacy, Department of Pharmacognosy, University of Belgrade, Belgrade, Serbia

Краткое описание

Cyclohexane, dichloromethane, and methanol extracts of the medicinal mushroom Laetiporus sulphureus were tested for their antimicrobial, cytotoxic, and radical scavenging activities. Total polyphenol content was also determined. Regarding the amount of the phenolic compounds in the methanol extract, there were 14.1 ± 0.6 mg gallic acid/g dry extract and a concentration of 0.66 ±0.15 mg/mL resulted in the removal of 50% of the DPPH radicals (half-maximal inhibitory concentration [IC50]) . The average minimum inhibitory concentrations (MICs) against a select panel of microorganisms were between 125 and 250 μg/mL, and the methanolic extract significantly inhibited the growth of Staphylococcus aureus (MIC, 31.25 μg/mL). Also, cyclohexane and dichloromethane extracts inhibited the growth of Helicobacter pylori (MIC, 62.5 μg/mL). Cyclohexane and dichloromethane extracts showed higher antiproliferative action compared with the methanol extract. The lowest IC50 was induced on HeLa cells by dichloromethane extract (IC50,67.20 ± 5.49 μg/mL), followed by cyclohexane extract (IC50 75.91 ± 1.57 μg/mL). The tested cyclohexane and dichloromethane extracts possessed moderate antibacterial and significant cytotoxic activity against both malignant (HeLa and N87) and healthy (MRC5) cell lines. Methanol extracts exhibited promising anti-Helicobacter activity without cytotoxicity against N87 and MRC5 cell lines.


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