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International Journal of Medicinal Mushrooms

Импакт фактор: 1.357

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v3.i1.50
4 pages

Ganoderma lucidum (Curt.: Fr.) P. Karst. and G. lipsiense (Batsch) Atk. Do Not Induce Micronuclei in Cultured Human Lymphocytes

Marie-Daniele Steinmetz
Laboratoire de Botanique, Cryptogamie et Biologie Cellulaire, Faculte de Pharmacie, 27 bd Jean Moulin-13385 Marseille Cedex 05, France
Jean-Pierre Rascol
Laboratoire de Botanique, Phytochimie et Mycologie, Faculte de Pharmacie, 15 Avenue Charles-Flabault-34060 Montpellier, France
Irene Sari-Minodier
Laboratoire de Biogenotoxicologie et Mutagenese Environnementale (UPRES EA-1784), Faculte de Medecine, 27 bd Jean Moulin-13385 Marseille Cedex 05, France
Thierry Orsiere
Laboratoire de Biogenotoxicologie et Mutagenese Environnementale (UPRES EA-1784), Faculte de Medecine, 27 bd Jean Moulin-13385 Marseille Cedex 05, France
Claude Andary
Faculty of Pharmacy, University of Montpellier 1.15 Av. Ch. Flahault, 34060, Montpellier Cedex 2, France
Patrick Regli
Laboratoire de Botanique, Cryptogamie et Biologie Cellulaire, Faculte de Pharmacie, 27 bd Jean Moulin-13385 Marseille Cedex 05, France
Alain Botta
Laboratoire de Biogenotoxicologie et Mutagenese Environnementale (UPRES EA-1784), Faculte de Medecine, 27 bd Jean Moulin-13385 Marseille Cedex 05, France

Краткое описание

Two Ganoderma species (G. lucidum and G. lipsiense, Ganodermatales) are regarded as popular remedies in Chinese and Japanese traditional medicine and their effectiveness seems to be reasonably acceptable. The cytokinesis-blocked micronucleus assay performed in vitro on human lymphocytes for several concentrations of crude extracts shows that these two mushroom species do not exhibit genotoxic properties (clastogenicity and/or aneugenicity). Moreover, no cytotoxic effect was detected at any dose.