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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i12.90
pages 1189-1199

Immune-Modulating Activity of Extract Prepared from Mycelial Culture of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes)

Sun-Hee Jang
Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju, Korea
Sae-Hae Kim
Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju, Korea; Department of Bioactive Materials and Research Center of Bioactive Materials, Chonbuk National University, Jeonju, Korea
Ha-Yan Lee
Department of Bioactive Materials and Research Center of Bioactive Materials, Chonbuk National University, Jeonju, Korea
Seung-Hwan Jang
Chebigen Inc., Jeonju, Korea
Hyonseok Jang
Department of Oral and Maxillofacial Surgery, Korea University Ansan Hospital, Ansan, Korea
Soo-Wan Chae
Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Korea; Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Korea
Su-Jin Jung
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Korea
Byung-Ok So
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Korea
Ki-Chan Ha
Healthcare Claims & Management Inc., Jeonju, Korea
Hong-Sig Sin
Chebigen Inc., Jeonju, Korea
Yong-Suk Jang
Department of Molecular Biology and the Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju, Korea; Department of Bioactive Materials and Research Center of Bioactive Materials, Chonbuk National University, Jeonju, Korea

Краткое описание

Ophiocordyceps sinensis is a natural fungus that has been valued as a health food and traditional Chinese medicine for centuries. The fungus is parasitic and colonizes insect larva. Naturally occurring O. sinensis thrives at high altitude in cold and grassy alpine meadows on the Himalayan mountain ranges. Wild O. sinensis is becoming increasingly rare in its natural habitats, and its price is out of reach for clinical practice. For these reasons, development of a standardized alternative is a great focus of research to allow the use of O. sinensis as a medicine. To develop an alternative for wild O. sinensis, a refined standardized extract, CBG-CS-2, was produced by artificial fermentation and extraction of the mycelial strain Paecilomyces hepiali CBG-CS-1, which originated from wild O. sinensis. In this study, we analyzed the in vivo immune-modulating effect of CBG-CS-2 in mice. Oral administration of CBG-CS-2 supported splenocyte stimulation and enhanced Th1-type cytokine expression from the splenocytes. Importantly, the same treatment significantly enhanced the natural killer cell activity of the splenocytes. Finally, oral administration of CBG-CS-2 enhanced the potential for inflammatory responses. Together, these findings indicate that the mycelial culture extract prepared from O. sinensis exhibited immune-modulating activity and suggest its possible use in the treatment of diseases caused by abnormal immune function.


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