Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
A Polysaccharide Isolated from Mycelia of the Lion’s Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells
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Краткое описание
Hericium erinaceus is typically used in traditional Chinese medicine for mucosal protection, healing of gastric ulcers, and treatment of gastritis. We purified from the cultured mycelia of H. erinaceus a polysaccharide with anti–gastric ulcer and antigastritis activity, but its effects on gastric malignancy have not been elucidated. We examined the differential effects of this purified polysaccharide, named EP-1, on the human gastric (GES-1) cell line and a precancerous cell line (MC) that was transformed from GES-1 using N-methyl-N'-nitro-N-nitrosoguanidine. We observed that the polysaccharide potently induced cell apoptosis and cell cycle arrest at the G0/G1 phase in the MC cell line but did not have any effect on the GES-1 cell line at the same doses. Further mechanistic studies revealed that the polysaccharide exerted its activity through an apoptosis-associated pathway by modulating the expression of Bax, Bcl-2, and caspase-3. Differential effects of the polysaccharide on the GES-1 and MC cell lines indicate that the polysaccharide was effective in preventing gastric cancer progression.
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Aras Aliye, Khalid Sumbul, Jabeen Saima, Farooqi Ammad Ahmad, Xu Baojun, Regulation of cancer cell signaling pathways by mushrooms and their bioactive molecules: Overview of the journey from benchtop to clinical trials, Food and Chemical Toxicology, 119, 2018. Crossref
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Chen Zhixia (Grace), Bishop Karen Suzanne, Tanambell Hartono, Buchanan Peter, Quek Siew Young, Assessment of In Vitro Bioactivities of Polysaccharides Isolated from Hericium Novae-Zealandiae, Antioxidants, 8, 7, 2019. Crossref
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Yang Liangjun, Li Jiali, Hu Zhipeng, Fan Xiangzhen, Cai Tiantian, Hengli Zhou , Pan Huafeng, A Systematic Review of the Mechanisms Underlying Treatment of Gastric Precancerous Lesions by Traditional Chinese Medicine, Evidence-Based Complementary and Alternative Medicine, 2020, 2020. Crossref
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Winder Mateusz, Bulska-Będkowska Weronika, Chudek Jerzy, The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology, Acta Pharmaceutica, 71, 1, 2021. Crossref
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Chen Liping, He Chunrong, Zhou Min, Long Jiaying, Li Ling, Research Progress on the Mechanisms of Polysaccharides against Gastric Cancer, Molecules, 27, 18, 2022. Crossref