Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.211 5-летний Импакт фактор: 1.394 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018025979
pages 393-403

Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms

Rosalia Rubel
Bioprocess Engineering and Biotechnology Division, Federal University of Paraná, Curitiba, Paraná, Brazil
Herta Stutz Dalla Santa
Bioprocess Engineering and Biotechnology Division, Federal University of Paraná, Curitiba, Paraná, Brazil
Leandro Freire dos Santos
Department of Pharmacy, Midwestern State University (UNICENTRO), Guarapuava, Paraná, Brazil
Luiz Claudio Fernandes
Department of Physiology, Federal University of Paraná, Curitiba, Paraná, Brazil
Bonald Cavalcante Figueiredo
Pelé Pequeno Príncipe Research Institute, Curitiba, Paraná, Brazil
Carlos Ricardo Soccol
Bioprocess Engineering and Biotechnology Division, Federal University of Paraná, Curitiba, Paraná, Brazil

Краткое описание

Medicinal mushrooms are used in popular medicine largely as health promoters, mainly because of their antitumor and immunomodulatory activities. Ganoderma lucidum (lingzhi or reishi) and Agaricus brasiliensis are mushrooms that have long been used for medicinal purposes. This study evaluated their immunomodulatory and antitumor effects on mice fed a diet supplemented with G. lucidum and A. brasiliensis mycelia obtained from solid-state fermentation. For 14 weeks the mice were fed chow containing 50% A. brasiliensis and G. lucidum mycelia, using ground wheat as an excipient. The consumption of the supplemented diet inhibited Sarcoma 180 tumor growth and caused important changes in the immune system. The pattern of immune response shifted, increasing CD4+ and CD8+ and decreasing CD19+ cell populations. The restoration of a proper balance between cellular and humoral immunity is an essential process for restraining tumor growth. These results suggest that polysaccharides, such as β-glucans and other mushroom metabolites, possibly promote the T-cell dominance that is imperative to restrain tumor growth.


Articles with similar content:

Induction of Dendritic Cells (DC) by Flt3 Ligand (FL) Promotes the Generation of Tumor-Specific Immune Responses In Vivo
Critical Reviews™ in Immunology, Vol.18, 1998, issue 1-2
David H. Lynch
High Immunomodulatory and Preventive Effects Against Sarcoma 180 in Mice Fed with Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Mycelium
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 1
Raffaello Di Bernardi, Rosalia Rubel, Jose Hermenio Cavalcante Lima Filho, Carlos Ricardo Soccol, Luiz Claudio Fernandes, Andrea N. Moreno, Fan Leifa, Herta Stutz Dalla Santa, Bonald Cavalcante Figueiredo
Immunomodulating Activity of Bjerkandera sp.
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Mark M. Shamtsyan, Valentina G. Konusova, Alexander M. Goloschev, Natalia V. Pigareva, Arina V. Korchmaryova
Antitumor and Immunomodulating Activities of Exopolysaccharide Produced by Big Cup Culinary- Medicinal Mushroom Clitocybe maxima (Higher Basidiomycetes) in Liquid Submerged Culture
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 9
Peter Chi Keung Cheung, Yu-Kuei Chen, Jinn-Chyi Wang, Shu-Hui Hu, Raw-Pou Hung, Sue-Joan Chang
T Lymphocytes and Their Cytokines in Human Immunodeficiency Virus (HIV) Infection: Implications for Associated Neoplasias
Critical Reviews™ in Oncogenesis, Vol.6, 1995, issue 3-6
Christian Jassoy, Bruce D. Walker