Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
A Water-Ethanol Extract from the Willow Bracket Mushroom, Phellinus igniarius (Higher Basidiomycetes), Reduces Transient Cerebral Ischemia-Induced Neuronal Death
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Краткое описание
This study investigated the potential neuroprotective effect of a mushroom extract from Phellinus igniarius (Piwep) after transient cerebral ischemia. Ph. Igniarius, which has a history of traditional medicinal use, contains immunomodulatory compounds that have been described to have effects on the human immune system. Using a model of transient cerebral ischemia induced by both common carotid artery occlusion and hypovolemia, a water−ethanol extract precipitate of Ph. Igniarius (Piwep) was delivered intraperitoneally immediately after the insult and was injected subsequently every other day for the experimental course. Neuronal death was examined by Fluoro-Jade B staining 1 week after the insult. Piwep injection lead to decreased hippocampal neuronal death, suppression of oxidative injury, activation of microglia, and disruption of the blood−brain barrier. We conclude that Piwep potently inhibits hippocampal neuronal death following ischemia and may have a high therapeutic potential for ameliorating stroke-induced neuron death in the clinical setting.
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Han Kyu-Hyun, Kim Ae-Kyeong, Kim Min-Hee, Kim Do-Hyung, Go Ha-Nl, Kang Donglim, Chang Jong Wook, Choi Soon Won, Kang Kyung-Sun, Kim Dong-ik, Protein profiling and angiogenic effect of hypoxia-cultured human umbilical cord blood-derived mesenchymal stem cells in hindlimb ischemia, Tissue and Cell, 49, 6, 2017. Crossref
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Zapora Ewa, Wolkowycki Marek, Bakier Slawomir, Zjawiony Jordan K., Phellinus igniarius: A Pharmacologically Active Polypore Mushroom, Natural Product Communications, 11, 7, 2016. Crossref
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Sarfraz Ayesha, Rasul Azhar, Sarfraz Iqra, Shah Muhammad Ajmal, Hussain Ghulam, Shafiq Nusrat, Masood Muqaddas, Adem Şevki, Sarker Satyajit D., Li Xiaomeng, Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways, Environmental Research, 190, 2020. Crossref
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Wang Fei-Fei, Shi Chao, Yang Yue, Fang Yong, Sheng Li, Li Ning, Medicinal mushroom Phellinus igniarius induced cell apoptosis in gastric cancer SGC-7901 through a mitochondria-dependent pathway, Biomedicine & Pharmacotherapy, 102, 2018. Crossref
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Sułkowska‐Ziaja Katarzyna, Balik Monika, Muszyńska Bożena, Selected Species of the Genus Phellinus – Chemical Composition, Biological Activity, and Medicinal Applications , Chemistry & Biodiversity, 18, 11, 2021. Crossref