Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
Indexed in
Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes)
Краткое описание
Hericium erinaceus is a culinary-medicinal mushroom that is used in traditional medicine, in folk medicine, and as medicinal cuisine in Asian countries such as China, Japan, and Korea. H. erinaceus exhibits various pharmacological properties, such as anti-cancer, immunomodulation, anti-dementia, and anti-gastric ulcer effects. The extracts of the fruiting body of H. erinaceus demonstrate anti-gastritis activity. However, the active principle in the extract, as well as the mechanism to treat gastric ulcers, remains uncertain. The current study aims to identify the active component, with anti-gastric ulcer function, from the extracts of the H. erinaceus mycelium culture. In the experiment, anti-gastric ulcer activity was evaluated using an ethanol-induced ulcer model in mice and with an 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay using MC cell lines. The results suggest that the polysaccharide fraction can significantly decrease the ulcerated area compared with the control group and the effect is fairly dose dependent, irrespective of animal or cell experiments. These results indicate that the polysaccharide fraction is the active component of the H. erinaceus mycelium culture, which protects against gastric ulcers.
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Wang Mingxing, Kanako Nakajima, Zhang Yanqiu, Xiao Xulang, Gao Qipin, Tetsuya Konishi, Gallyas Ferenc, A unique polysaccharide purified from Hericium erinaceus mycelium prevents oxidative stress induced by H2O2 in human gastric mucosa epithelium cell, PLOS ONE, 12, 7, 2017. Crossref
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Wang Xiao-Yin, Yin Jun-Yi, Zhao Ming-Ming, Liu Shi-Yu, Nie Shao-Ping, Xie Ming-Yong, Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities, Carbohydrate Polymers, 186, 2018. Crossref
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Yuan Erdong, Liu Liangyun, Huang Min, Chang Bo, Qi Chunli, Gou Na, Ren Jiaoyan, Effects of complex extracts of traditional Chinese herbs on gastric mucosal injury in rats and potential underlying mechanism, Food Frontiers, 2, 3, 2021. Crossref
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Zhang Feng, Lv Hui, Zhang Xuhua, Erinacerins, Novel Glioma Inhibitors from Hericium erinaceus, Induce Apoptosis of U87 Cells through Bax/Capase-2 Pathway, Anti-Cancer Agents in Medicinal Chemistry, 20, 17, 2020. Crossref
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Liu Jianhui, Wang Weiwei, Hu Qiuhui, Wu Xuyang, Xu Hui, Su Anxiang, Xie Minhao, Yang Wenjian, Bioactivities and molecular mechanisms of polysaccharides from Hericium erinaceus, Journal of Future Foods, 2, 2, 2022. Crossref
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Shao Shuai, Wang Dandan, Zheng Wei, Li Xiangyan, Zhang He, Zhao Daqing, Wang Mingxing, A unique polysaccharide from Hericium erinaceus mycelium ameliorates acetic acid-induced ulcerative colitis rats by modulating the composition of the gut microbiota, short chain fatty acids levels and GPR41/43 respectors, International Immunopharmacology, 71, 2019. Crossref
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Wang Xiao‐Yin, Yin Jun‐Yi, Hu Jie‐Lun, Nie Shao‐Ping, Xie Ming‐Yong, Gastroprotective polysaccharide from natural sources: Review on structure, mechanism, and structure–activity relationship, Food Frontiers, 2022. Crossref