Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i3.30
pages 251-266

Antioxidant and Immunomodulating Activities of Exo-and Endopolysaccharide Fractions from Submerged Mycelia Cultures of Culinary-Medicinal Mushrooms

Sang-Chul Jeong
School of Science and Health, University of Western Sydney, Penrith New South Wales, Australia; Department of Pharmaceutical Engineering, Daegu Haany University, Gyeongsan, Gyeongbuk, Korea
Sundar Rao Koyyalamudi
School of Science and Health, University of Western Sydney, Penrith New South Wales, Australia
J. Margaret Hughes
Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia
Cheang Khoo
School of Science and Health, University of Western Sydney, Penrith New South Wales, Australia
Trevor Bailey
School of Science and Health, University of Western Sydney, Penrith New South Wales, Australia
Karthik Marripudi
Gosford Hospital, Gosford, New South Wales, Australia
Jong Pil Park
Department of Pharmaceutical Engineering, Daegu Haany University, Gyeongsan, Gyeongbuk, Korea
Jin Hee Kim
Institute of Medical Science, Hallym University, Chuncheon, Republic of Korea
Chi-Hyun Song
Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, Korea

Краткое описание

A number of mushrooms are known to possess pharmacological activities. In this study, the phenolic and flavonoid contents of extracts of exo- and endopolysaccharide fractions obtained from submerged mycelia cultures of 7 edible or medicinal mushroom species, as well as their antioxidant and immunomodulatory properties, were evaluated. The exo- and endopolysaccharide yields were 0.576−1.950 and 0.438−0.933 g/L, respectively. The sugar and protein contents of these fractions were analyzed and contained predominantly sugars (52.3−87.6%). The exo- and endopolysaccharide fractions contained appreciable amounts of phenolics and flavonoids. The highest flavonoid contents were found in Cryptosporus volvatus (349.6 mg/g), followed by Cordyceps militaris (312.6 mg/g). The antioxidant activities were evaluated by 4 assays: biological assay using Saccharomyces cerevisiae, DPPH radical scavenging activity, chelating ability for ferrous ions and ferric reducing antioxidant power. The mycelia polysaccharide fractions had more ferric reducing antioxidant power than other antioxidant activities. Both exo- and endo polysaccharides of C. volvatus inhibited production of the T lymphocyte Th1 cytokines interferon (IFN)-γ and interleukin (IL)-2, the Th2 cytokines IL-4 and IL-5, and macrophage enzyme activity. Although those from C. militaris had similar inhibitory effects on cytokine production, the exopolysaccharides stimulated macrophage enzyme activity. The other exopolysaccharides (Pleurotus citrinopileatus, P. australis, and P. pulmonarius) inhibited IFN-γ and IL-5 production, but they had varying effects on IL-2 and IL-4 production. Only 3 exopolysaccharides (P. pulmonarius, Tremella mesenterica, and Cordyceps sinensis) also stimulated macrophage enzyme activity to the same extent as lipopolysaccharides. All of them reduced IL-5 production, but those from T. mesenterica also inhibited IFN-γ, IL-2, and IL-4 production. Thus the polysaccharide fractions from the mushrooms studied have antioxidant activities and general immunomodulating effects in vitro.


Articles with similar content:

Antioxidant and Enzyme Inhibitory Activities of Extracts from Wild Mushroom Species from Turkey
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 4
Abdurrahman Aktumsek, Gokhan Zengin, Mehmet Sefa Kocak, Mehmet Cemil Uren, Marcello Locatelli, Halil Gungor, Cengiz Sarikurkcu
Activity-Guided Fractionation and Evaluation of Potent Antioxidants from Extract of Angel Wings Mushroom, Pleurotus porrigens (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 1
Hip Seng Yim, Fook Yee Chye, Chun Wai Ho, Chiaw Mei Sia, Loshnie Samuagam, Sook Yee Mah
Comparative Cytotoxicity and Hemagglutination Activities of Crude Protein Extracts from Culinary-Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 2
Renee Lay Hong Lim, Suan Li Lee, Jin Ying Leong
Antioxidant and Anti-Inflammatory Properties of Solid-State Fermented Products from a Medicinal Mushroom, Taiwanofungus salmoneus (Higher Basidiomycetes) from Taiwan
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 1
Shen-Shih Chiang, Jeng-Leun Mau, Enkhjargal Ulziijargal , Rao-Chi Chien
Anti-Inflammatory Effects of Extracts from the Medicinal Mushrooms Hypsizygus marmoreus and Pleurotus eryngii (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 6
Jeng-Leun Mau, Yi-Chi Yang, Eric Icheng Lai, Rao-Chi Chien