Доступ предоставлен для: Guest
International Journal of Medicinal Mushrooms
Главный редактор: Solomon P. Wasser (open in a new tab)

Выходит 12 номеров в год

ISSN Печать: 1521-9437

ISSN Онлайн: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Mycelia Attenuates Doxorubicin-Induced Oxidative Stress and Upregulates Krebs Cycle Dehydrogenases Activity and ATP Level in Rat Brain

Том 22, Выпуск 6, 2020, pp. 593-604
DOI: 10.1615/IntJMedMushrooms.2020035093
Get accessGet access

Краткое описание

Post-chemotherapy-induced cognitive dysfunction remains one of the challenges in cancer survivors. Cytokine-induced neurotoxicity manifests in subjects at any time after doxorubicin (DOX) chemotherapy. We examined the effect of bioactive Cordyceps militaris mycelia extract (CM) on the energy status, oxidative stress, and acetylcholinesterase activity in the brain of DOX treated rats. The CM (150 and 300 mg/kg b.w.) and DL-α lipoic acid (LA, 100 mg/kg b.w) were administered orally once daily for 5 days to male Wistar rats prior to the DOX administration (18 mg/kg as 3 doses of 6 mg/kg, i.p. b.w.) and continued for 6 more days. Cellular antioxidant status, Krebs cycle dehydrogenases, electron transport chain complexes (ETC) (I, III, and IV), adenosine triphosphate (ATP) level, advanced oxidation of protein products (AOPP), and acetylcholinesterase (AchE) activities were determined in the brain homogenate. The DOX alone treated group of animals showed significant decrease (p < 0.05) of brain antioxidant levels, Krebs cycle dehydrogenases activities, ETC complex activities, and decreased ATP level, while lipid peroxidation and AOPP levels were elevated. CM at 300 mg/kg b.w. or LA at 100 mg/kg b.w. elevated antioxidant status, Krebs cycle dehydrogenases, and complex activities and thus alleviated the toxicity. CM also inhibited the AchE activity in brain. The experimental results thus reveal that CM possessed excellent capacity to attenuate oxidative stress, upregulate respiratory chain complex activity and ATP levels, as well as inhibition of AchE activity.

ЛИТЕРАТУРА
  1. Ahles TA, Saykin AJ. Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer. 2007;7:192-201.

  2. Nelson CJ, Nandy N, Roth AJ. Chemotherapy and cognitive deficits: Mechanisms, findings and potential interventions. Palliat Support Care. 2007;5:273-80.

  3. Wasser SP. Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological and immunomodulatory activities: A review. Int J Med Mushrooms. 2017;19(4):279-317.

  4. Di Iulio F, Cravello L, Shofany J, Paolucci S, Caltagirone C, Morone G. Neuropsychological disorders in non-central nervous system cancer: A review of objective cognitive impairment, depression, and related rehabilitation options. Neurol Sci. 2019;40(9):1759-74.

  5. Chiang ACA, Huo X, Kavelaars A, Heijnen CJ. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain Behav Immun. 2019;79:319-25.

  6. Weiss RB. The anthracyclines: Will we ever find a better doxorubicin? Semin Oncol. 1992;19:670-86.

  7. Kuznetsov AV, Margreiter R, Amberger A, Saks V, Grimm M. Kuznetsova AV. Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death. Biochim Biophys Acta. 2011;1813:1144-52.

  8. Chae JW, Ng T, Yeo HL, Shwe M, Gan YX, Ho HK, Chan A. Impact of TNF-a (rs1800629) and IL-6 (rs1800795) polymorphisms on cognitive impairment in Asian breast cancer patients. PLoS One. 2016;11:e0164204.

  9. Lyon DE, Cohen R, Chen H, Kelly DL, Starkweather A, Ahn H, Jackson-Cook CK. The relationship of cognitive performance to concurrent symptoms, cancer- and cancer-treatment-related variables in women with early-stage breast cancer: A 2-year longitudinal study. J Cancer Res Clin Oncol. 2016;142:1461-74.

  10. Abd El-Gawad HM, El-Sawalhi MM. Nitric oxide and oxidative stress in brain and heart of normal rats treated with doxorubicin: Role of aminoguanidine. J Biochem Mol Toxicol. 2004;18:69-77.

  11. Bagnall-Moreau C, Chaudhry S, Salas-Ramirez K, Ahles T, Hubbard K. Chemotherapy-induced cognitive impairment is associated with increased inflammation and oxidative damage in the hippocampus. Mol Neurobiol. 2019;56:7159-72.

  12. Patten DA, Germain M, Kelly MA, Slack RS. Reactive oxygen species: Stuck in the middle of neurodegeneration. J Alzheimers Dis. 2010;20:S357-67.

  13. Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, Moreira PI. Doxorubicin: The good, the bad and the ugly effect. Curr Med Chem. 2009;16:3267-85.

  14. Jung SJ, Jung ES, Choi EK, Sin HS, Ha KC, Chae SW. Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): A randomized and double-blind clinical trial. BMC Complement Altern Med. 2019;19:77-84.

  15. Qiao J, Shuai Y, Zeng X, Xu D, Rao S, Zeng H, Li F. Comparison of chemical compositions, bioactive ingredients, and in vitro antitumor activity of four products of Cordyceps (Ascomycetes) strains from China. Int J Med Mushrooms. 2019;21:331-42.

  16. Dong CH, Yang T, Lian T. A comparative study of the antimicrobial, antioxidant, and cytotoxic activities of methanol extracts from fruit bodies and fermented mycelia of caterpillar medicinal mushroom Cordyceps militaris (Ascomycetes). Int J Med Mushrooms. 2014;16:485-95.

  17. Nurmamat E, Xiao H, Zhang Y, Jiao Z. Effects of different temperatures on the chemical structure and antitumor activities of polysaccharides from Cordyceps militaris. Polymers (Basel). 2018;10(4):430.

  18. Ong BY, Aziz Z. Efficacy of Cordyceps sinensis as an adjunctive treatment in kidney transplant patients: A systematic-review and meta-analysis. Complement Ther Med. 2017;30:84-92.

  19. Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients. Cochrane Database Syst Rev. 2015 Oct 12;(10):CD009698.

  20. Kayali R, Cakatay U, Uzun H, Genc H. Gender difference as regards myocardial protein oxidation in aged rats: Male rats have increased oxidative protein damage. Biogerontology. 2007;8:653-61.

  21. Ellman GL, Diane CK, Valentino A Jr, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1960;7:88-95.

  22. Ajith TA, Sudheesh NP, Roshny D, Abishek G, Janardhanan KK. Effect of Ganoderma lucidum on the activities of mitochondrial dehydrogenases and complex I and II of electron transport chain in the brain of aged rats. Exp Gerontol. 2009;44:219-23.

  23. Fatania H, Al-Nassar EK, Sidhan V. Purification and partial characterization NADP'-linked isocitrate dehydrogenase from rat of liver cytosol. FEBS Lett. 1993;320:57-60.

  24. Reed LJ, Mukherjee BB. a-ketoglutarate dehydrogenase complex from Escherichia coli. Methods Enzymol. 1969;13:55-61.

  25. Nulton-Persson AC, Szweda LI. Modulation of mitochondrial function by hydrogen peroxide. J Biol Chem. 2001; 276:23357-61.

  26. Mehler AH, Kornberg A, Grisolia S, Ochia S. The enzymatic mechanisms of oxidation and reduction between malate or isocitrate and pyruvate. J Biol Chem. 1948;174:961-71.

  27. Janssen MJA, Trijbels MJ, Sengers ACR, Smeitink MJA, van den Heuvel PL, Wintjes MTL, Stoltenborg-Hogenkamp MJB, Rodenburg TJR. Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts. Clin Chem. 2007;53:729-31.

  28. Krahenbuhl S, Chang M, Brass EP, Hoppel CL. Decreased activities of ubiquinol: Ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c: Oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin [c lactam]-induced methylmalonic aciduria. J Biol Chem. 1991;266:20998-30003.

  29. Capaldi RA, Marusich MF, Taanman JW. Mammalian cytochrome-c oxidase: Characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells. Methods Enzymol. 1995;260:117-32.

  30. Lowry HD, Rosenberg NJ, Farr AL, Randa RJ. Protein measurement with Folin phenol reagent. J Biol Chem. 1951; 193:265-75.

  31. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochimica Biophysica Acta. 1979;582:67-78.

  32. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thibarbituric acid reaction. Anal Biochem. 1979;95:351-8.

  33. McCord JM, Fridovich I. Superoxide dismutase. An enzymatic function for erythrocuprein (hemocuprein). J Biol Chem. 1969;244:6049-55.

  34. Hafeman DG, Sunde RA, Hoekstra WG. Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J Nutr. 1947;104:580-7.

  35. Beers JR, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 1952;195:133-40.

  36. Gewirtz DA. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol. 1997;57:727-41.

  37. De Atley SM, Aksenov MY, Akensova MV, Carney JM, Butterfield DA. Adriamycin induces protein oxidation in erythrocyte membranes. Pharmacol Toxicol. 1998;83:62-68.

  38. Tacar O, Sriamornsak P, Dass CR. Doxorubicin: An update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2012;65:157-70.

  39. Tangpong J, Cole MP, Sultana R, Joshi G, Estus S, Vore M, St Clair W, Ratanachaiyavong S, St Clair DK, Butterfield DA. Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity. Neurobiol Dis. 2006;23:127-39.

  40. Minotti G. Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 2004;56:185-229.

  41. Gorini S, De Angelis A, Berrino L, Malara N, Rosano G, Ferraro E. Chemotherapeutic drugs and mitochondrial dysfunction: Focus on doxorubicin, trastuzumab, and sunitinib. Oxid Med Cell Longev. 2018;2018:7582730.

  42. Nissanka N, Moraes CT. Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease. FEBS Lett. 2017;592:728-42.

  43. Tuli H, Sardul SS, Sharma AK. Pharmacological and therapeutic potential of Cordyceps with special reference to cordycepin. 3 Biotech. 2014;4:1-12.

  44. Zhang J, Wen C, Duan Y, Zhang H, Ma H. Advance in Cordyceps militaris (Linn) Link polysaccharides: Isolation, structure and bioactivities: A review. Int J Biol Macromol. 2019;132:906-14.

ЦИТИРОВАНО В
  1. Parunyakul Kongphop, Srisuksai Krittika, Charoenlappanit Sawanya, Phaonakrop Narumon, Roytrakul Sittiruk, Fungfuang Wirasak, Souza-Mello Vanessa, Metabolic impacts of cordycepin on hepatic proteomic expression in streptozotocin-induced type 1 diabetic mice, PLOS ONE, 16, 8, 2021. Crossref

  2. Deshmukh Loknath, Singh Rajendra, Singh Sandhu Sardul, Broad Efficacy of Scavenging Free Radicals: Cordyceps sp., in Antioxidants - Benefits, Sources, Mechanisms of Action, 2021. Crossref

  3. Raghu Shamprasad Varija, Kudva Avinash Kundadka, Rao Suresh, Prasad Krishna, Mudgal Jayesh, Baliga Manjeshwar Shrinath, Dietary agents in mitigating chemotherapy-related cognitive impairment (chemobrain or chemofog): first review addressing the benefits, gaps, challenges and ways forward, Food & Function, 12, 22, 2021. Crossref

  4. Jędrejko Karol Jerzy, Lazur Jan, Muszyńska Bożena, Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity, Foods, 10, 11, 2021. Crossref

  5. He Yu-fei, Mai Chu-tian, Pan Hu-dan, Liu Liang, Zhou Hua, Xie Ying, Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis, Chinese Herbal Medicines, 13, 4, 2021. Crossref

  6. Lv Qin , Di Xiaoyan , Bian Bo , Li Kai , Guo Jianyou , Neuroprotective Effects of Poria cocos (Agaricomycetes) Essential Oil on A&beta;1-40-Induced Learning and Memory Deficit in Rats , International Journal of Medicinal Mushrooms, 24, 10, 2022. Crossref

2794 Просмотры статей 45 Загрузка статей Метрики
2794 ПРОСМОТРЫ 45 ЗАГРУЗКИ 6 Crossref ЦИТАТЫ Google
Scholar
ЦИТАТЫ

Статьи с похожим содержанием:

Extract of Caterpillar Medicinal Mushroom, Cordyceps milifaris (Ascomycetes), Mycelia Attenuates Doxorubicin-Induced Cardiotoxicity and Upregulates Mitochondrial Electron Transport Chain Activity in Rats International Journal of Medicinal Mushrooms, Vol.23, 2021, issue 1
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor Krishnankutty Janardhanan, Solomon P. Wasser, Ravindran Kalathil Veena, Haridas Ramya
Reversal of Carbon Tetrachloride-Induced Hepatic Injury by Aqueous Extract of Artemisia absinthium in Sprague-Dawley Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 4
Monika Sharma, Sangeeta Shukla
The Hepatoprotective Effect of Clidemia hirta against Carbon Tetrachloride (CCl4)−Induced Oxidative Stress and Hepatic Damage in Mice Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 4
Mohammad Iqbal, Nurul Amzar
Therapeutic Efficacy of Rosa damascena Mill. on Acetaminophen-Induced Oxidative Stress in Albino Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 3
Neetu Sharma, Sadhana Shrivastava, Arvind Shakya, Monika Sharma, Sangeeta Shukla
Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain