Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024504
pages 981-990

Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats

Jaweria Nisar
Department of Physiology, Government College University, Faisalabad, Pakistan
Imtiaz Mustafa
Department of Physiology, Government College University, Faisalabad, Pakistan
Haseeb Anwar
Department of Physiology, Government College University, Faisalabad, Pakistan
Muhammad Umar Sohail
Department of Physiology, Government College University, Faisalabad, Pakistan
Ghulam Hussain
Department of Physiology, Government College University, Faisalabad, Pakistan
Muhammad Irfan Ullah
Department of Pathobiology, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, Pakistan
Muhammad Naeem Faisal
Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan
Shazia Anwer Bukhari
Department of Biochemistry, Government College University Faisalabad, Pakistan
Abdul Basit
Remount Office, Chenab Breeding Area, Faisalabad, Pakistan

Краткое описание

Lentinus edodes is a culinary-medicinal mushroom that has an established history of use in Asian therapies. The mushroom offers well-documented beneficial health effects such as antihypercholesterolemic, antitumor, and antibacterial activities. In this study, dried powder of L. edodes fruiting bodies was used to evaluate immunomodulatory, hepatoprotective, and antioxidant effects in hypercholesterolemic rats. Albino rats (n = 24) were divided into 3 groups: the control (CON) group, the hypercholesterolemia-only group (HCG), and the L. edodes group (LEG). Hypercholesterolemia was induced in rats in the HCG and LEG by feeding cholesterol and cholic acid in a chow maintenance diet (CMD) for 24 days. The CON group was fed the CMD throughout the experiment. The HCG continued on the high-cholesterol diet without any L. edodes supplement. The LEG was fed the high-cholesterol diet supplemented with L. edodes for an additional 42 days. Various biological health biomarkers, such as total antioxidant capacity, total oxidant status, arylesterase, paraoxonase activity, and liver enzymes in serum were studied to evaluate antioxidant and hepatoprotective responses. Cell-mediated immunity was evaluated in each group through a delayed type of hypersensitivity reaction. The total oxidant status decreased significantly (P ≤ 0.05) after administration of L. edodes in the diet. The cell-mediated immune response significantly increased (P ≤ 0.05) in the LEG. The significant decrease in liver enzymes supports the hepatoprotective effect of L. edodes. In conclusion, the results show the immunomodulatory, hepatoprotective, and antioxidant activities of L. edodes supplementation in hypercholesterolemic rats.

Articles with similar content:

The Protective Effects of Aqueous Extracts of Wild-Growing and Fermented Royal Sun Mushroom, Agaricus brasiliensis S. Wasser et al. (Higher Basidiomycetes), in CCl4-Induced Oxidative Damage in Rats
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 6
Haitao Yu, Baosheng Zhao, Chunchao Han, Chunjing Zhang
The Effects of the King Oyster Mushroom Pleurotus eryngii (Higher Basidiomycetes) on Glycemic Control in Alloxan-Induced Diabetic Mice
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 3
Huan Zhan, Ya-li Lei, Jian-Ping Li
Ethanolic Extract of the Golden Oyster Mushroom, Pleurotus citrinopileatus (Agaricomycetes), Alleviates Metabolic Syndrome in Diet-Induced Obese Mice
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Changhui Zhao, Quanbo Chi, Kunlun Huang, Pengfei Shi, Guoyi Wang, Yao Sheng, Wentao Xu
Hypocholesterolemic Effects of the Cauliflower Culinary-Medicinal Mushroom, Sparassis crispa (Higher Basidiomycetes), in Diet-Induced Hypercholesterolemic Rats
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 10
Hyung Joo Suh, Song-Hwan Bae, Sung-Yong Hong, Eun Young Joung, Byung Hee Kim, Yooheon Park, Ki Bae Hong
Chemopreventive Effect of Cardamom (Elettaria cardamomum L.) Against Benzo(α)Pyrene-Induced Forestomach Papillomagenesis in Swiss Albino Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 2
Sasikumar Dhanarasu, Mo'ez Al-Islam Faris, Samir Qiblawi