Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.211 5-летний Импакт фактор: 1.394 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i4.20
pages 345-355

Royal Sun Medicinal Mushroom Agaricus brasiliensis (Higher Basidiomycetes) and the Attenuation of Pulmonary Inflammation Induced by 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK)

Carolina Croccia
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Agnaldo Jose Lopes
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Luis Felipe Ribeiro Pinto
Department of Biochemistry, Institute of Biology Alberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, RJ
Armando Ubirajara Oliveira Sabaa-Srur
Department of Experimental Basic Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, RJ
Luiz Carlos Aguiar Vaz
Department of Anatomical Pathology, State University of Rio de Janeiro, Rio de Janeiro, RJ
Marcele Nogueira de Sousa Trotte
Department of Anatomical Pathology, State University of Rio de Janeiro, Rio de Janeiro, RJ
Bernardo Tessarollo
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ
Aristofanes Correa Silva
Technology Centre, Federal University of Maranhao, Sao Luis, Brazil
Haroldo Jose de Matos
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ
Rodolfo Acatauassu Nunes
University Centre for Cancer Control, State University of Rio de Janeiro, Rio de Janeiro, RJ

Краткое описание

Agaricus brasiliensis currently is one of the most studied fungi because of its nutritional and therapeutic properties as an anti-inflammatory agent and an adjuvant in cancer chemotherapy. The effects of orally administered aqueous A. brasiliensis extract (14.3- and 42.9-mg doses) on parenchymal lung damage induced by carcinogenic 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were observed in Wistar rats. NNK treatment induced pulmonary inflammation, but not lung cancer, in the rats. The lungs of animals treated with NNK showed a higher level of inflammation than those of the control group according to histopathologic examinations (P < 0.01) and kurtosis analysis (P < 0.001) of a global histogram generated from thoracic computed tomography scans. There was no significant difference in the alveolar and bronchial exudates between animals treated with a 14.3-mg dose of A. brasiliensis extract and the control without NNK. However, a significant difference was found between animals treated with NNK, received a 42.9-mg dose of A. brasiliensis (P < 0.05), and the controls not treated with NNK. We did not observe a significant difference between the kurtoses of the A. brasiliensis (14.3 mg) and control groups. However, a 42.9-mg dose of A. brasiliensis resulted in lower kurtosis values than those observed in the control group (P < 0.001). In conclusion, a low dose of A. brasiliensis was more effective in attenuating pulmonary inflammation. Similar to the histopathological results, the computed tomography scans also showed a protective effect of A. brasiliensis at the lower dose, which prevented gross pulmonary consolidation.


Articles with similar content:

Zoledronic Acid Aggravates Kidney Damage During Ischemia Reperfusion Injury in Rat
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 1
Orhan Unal Zorba, Levent Tumkaya, Ahmet Fikret Yucel, Ibrahim Sehitoglu, Medine Cumhur Cure, Erkan Cure, Suleyman Yuce, Recep Bedir, Yildiray Kalkan
Antioxidant and Radiation Antagonistic Effect of Saraca indica
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 1
P. Gayathri, P. R. Archana, Bola Sadashiva Satish Rao, Prerana Shetty, Nageshwar Rao
Protective Effect of Troxerutin on Nickel-Induced Testicular Toxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 2
Ramalingam Ramakrishnan, Abdulkadhar Mohamed Jalaludeen, Leelavinothan Pari, Perumal Elangovan
The Protective Effects of Aqueous Extracts of Wild-Growing and Fermented Royal Sun Mushroom, Agaricus brasiliensis S. Wasser et al. (Higher Basidiomycetes), in CCl4-Induced Oxidative Damage in Rats
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 6
Haitao Yu, Baosheng Zhao, Chunchao Han, Chunjing Zhang
Hepatoprotective Effects and Mechanisms of Action of Triterpenoids from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on α-Amanitin-Induced Liver Injury in Mice
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 9
Shanshan Tang, Zuohong Chen, Zhaoqin Huang, Qian Zhou, Ping Zhang, Huihui Wu