Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
Indexed in
Immunomodulating Activity of a b-Glucan Preparation, SCG, Extracted from a Culinary–Medicinal Mushroom, Sparassis crispa Wulf.:Fr. (Aphyllophoromycetideae), and Application to Cancer Patients
Краткое описание
Sparassis crispa (SC) is culinary–medicinal mushroom recently cultivated in Japan, China, Germany, and the US. We purified a 6-branched 1.3-b-D-glucan preparation designated as SCG. SCG increased the number of leukocytes and enhanced the activity of leukocytes from various points of view, mainly analyzed in experimental animals. In the present study, the cytokine capacity of SCG was examined in healthy volunteers in vitro, and the following characteristics were studied: SCG enhanced cytokine synthesis of whole blood cell culture dose dependently. A complement fragment, C5a, was released by SCG dependently upon dose. And anti-SCG natural antibody was detected in human plasma. From these facts, SCG has the capacity to activate human leukocytes and related immune systems. In a clinical trial, powder of SC (300 mg/day) was given orally to several cancer patients (lung, stomach, colon, breast, ovarian, uterine, prostate, pancreas, liver) after one course of treatment of lymphocyte transfer immunotherapy and follow-up for several months. Performance status of 14 cases were monitored and 9 cases were improved as CR (4), PR (5), and NC (5). These facts strongly suggest that Sparassis crispa is a good source for cancer immunotherapy.
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Yamamoto Kyosuke, Nishikawa Yoshihiro, Kimura Takashi, Dombo Munehiko, Matsuura Nariaki, Sugitachi Akio, Antitumor Activities of Low Molecular Weight Fraction Derived from the Cultured Fruit Body of Sparassis crispa in Tumor-Bearing Mice, Nippon Shokuhin Kagaku Kogaku Kaishi, 54, 9, 2007. Crossref
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Cultural Characteristics of Cauliflower Mushroom, Sparassis crispa, The Korean Journal of Mycology, 36, 1, 2008. Crossref
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Harada Toshie, Ohno Naohito, Contribution of dectin-1 and granulocyte macrophage–colony stimulating factor (GM-CSF) to immunomodulating actions of β-glucan, International Immunopharmacology, 8, 4, 2008. Crossref
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Harada Toshie, Kawaminami Hiromi, Miura Noriko N., Adachi Yoshiyuki, Nakajima Mitsuhiro, Yadomae Toshiro, Ohno Naohito, Cell to Cell Contact Through ICAM-1-LFA-1 and TNF-α Synergistically Contributes to GM-CSF and Subsequent Cytokine Synthesis in DBA/2 Mice Induced by 1,3-β-D-Glucan SCG, Journal of Interferon & Cytokine Research, 26, 4, 2006. Crossref
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De Silva Dilani D., Rapior Sylvie, Fons Françoise, Bahkali Ali H., Hyde Kevin D., Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action, Fungal Diversity, 55, 1, 2012. Crossref
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Harada Toshie, Miura Noriko N., Adachi Yoshiyuki, Nakajima Mitsuhiro, Yadomae Toshiro, Ohno Naohito, Highly Expressed Dectin-1 on Bone Marrow-Derived Dendritic Cells Regulates the Sensitivity to β-Glucan in DBA/2 Mice, Journal of Interferon & Cytokine Research, 28, 8, 2008. Crossref
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Hida Toshie H., Kawaminami Hiromi, Ishibashi Ken-ichi, Miura Noriko N., Adachi Yoshiyuki, Yadomae Toshiro, Ohno Naohito, Effect of GM-CSF on cytokine induction by soluble β-glucan SCGin vitroin β-glucan-treated mice, Microbiology and Immunology, 53, 7, 2009. Crossref
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Harada Toshie, Miura Noriko N., Adachi Yoshiyuki, Nakajima Mitsuhiro, Yadomae Toshiro, Ohno Naohito, Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Regulates Cytokine Induction by 1,3-β-D-Glucan SCG in DBA/2 MiceIn Vitro, Journal of Interferon & Cytokine Research, 24, 8, 2004. Crossref
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Selim Manal S., Amer Shaimaa K., Mohamed Sahar S., Mounier Marwa M., Rifaat Hala M., Production and characterisation of exopolysaccharide from Streptomyces carpaticus isolated from marine sediments in Egypt and its effect on breast and colon cell lines, Journal of Genetic Engineering and Biotechnology, 16, 1, 2018. Crossref
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Yoshikawa Kazuko, Kokudo Naoki, Hashimoto Toshihiro, Yamamoto Kyosuke, Inose Toshiaki, Kimura Takashi, Novel Phthalide Compounds from <i>Sparassis crispa</i> (Hanabiratake), Hanabiratakelide A—C, Exhibiting Anti-cancer Related Activity, Biological & Pharmaceutical Bulletin, 33, 8, 2010. Crossref
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Nie Shaoping, Cui Steve W., Xie Mingyong, Beta-Glucans and Their Derivatives, in Bioactive Polysaccharides, 2018. Crossref
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Hyder Md Salman, Dutta Sayan Deb, Mushroom-derived polysaccharides as antitumor and anticancer agent: A concise review, Biocatalysis and Agricultural Biotechnology, 35, 2021. Crossref
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Park Hyuk-Gu, Shim Youn Young, Choi Seung-Oh, Park Won-Mok, New Method Development for Nanoparticle Extraction of Water-Soluble β-(1→3)-d-Glucan from Edible Mushrooms, Sparassis crispa and Phellinus linteus, Journal of Agricultural and Food Chemistry, 57, 6, 2009. Crossref
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Bang Sunghee, Chae Hee-Sung, Lee Changyeol, Choi Hyun Gyu, Ryu Jiyoung, Li Wei, Lee Hanna, Jeong Gil-Saeng, Chin Young-Won, Shim Sang Hee, New Aromatic Compounds from the Fruiting Body of Sparassis crispa (Wulf.) and Their Inhibitory Activities on Proprotein Convertase Subtilisin/Kexin Type 9 mRNA Expression, Journal of Agricultural and Food Chemistry, 65, 30, 2017. Crossref
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Sharma Neha, Tapwal Ashwani, Verma Rachna, Kumar Dinesh, Nepovimova Eugenie, Kuca Kamil, Medicinal, nutritional, and nutraceutical potential of Sparassis crispa s. lat.: a review, IMA Fungus, 13, 1, 2022. Crossref
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Tada Rui, Harada Toshie, Nagi-Miura Noriko, Adachi Yoshiyuki, Nakajima Mitsuhiro, Yadomae Toshiro, Ohno Naohito, NMR characterization of the structure of a β-(1→3)-d-glucan isolate from cultured fruit bodies of Sparassis crispa, Carbohydrate Research, 342, 17, 2007. Crossref
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Okumura Ryosuke, Nakamura Yoshitoshi, Asada Chikako, Efficiency of β-glucan production by Sparassis crispa depends on mycelium shape, Biomass Conversion and Biorefinery, 2022. Crossref