Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Antitumor Effect of Culinary-Medicinal Oyster Mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., Derived Protein Fraction on Tumor-Bearing Mice Models
Get access
Краткое описание
Previously, we reported the in vitro anticancer and immunomodulatory effect of a protein fraction designated as Cibacron blue affinity purified protein (CBAEP) obtained from the culinary-medicinal oyster mushroom, Pleurotus ostreatus. In the present study, we investigated the in vivo antitumor potential of CBAEP in different tumor-bearing mice models and studied the detailed mechanism of tumor regression in Dalton lymphoma (DL)-bearing mice. The lethal dose (LD50) of CBAEP was found to be 55 mg/kg body weight and sublethal doses (5 mg/kg and 10 mg/kg body weight) showed a prolonged tumor survival time in DL, Sarcoma-180, and B16F0 melanoma tumor-bearing mice. Further, CBAEP reduced about 35.68 and 51.43% DL cell growth in 5 and 10 mg/kg body weight, respectively. The in vivo CBAEP treatment showed an apoptotic feature as demonstrated in morphological study and sub-G0/G1 population in cell cycle and Western blot of DL cells. CBAEP also activated immunosuppression condition in DL tumor-bearing host. It also stimulated immune cells in the presence of nonspecific immunostunulator (LPS and ConA) ex vivo as well as enhanced Th1 response with production of TNF-α, IFN-γ, and IL-2. Moreover, it activated tumor-associated macrophages and NK cells. The present findings revealed the potent antitumor property of CBAEP, which might help in developing a new anticancer drug.
-
Raman Jegadeesh, Reddy G. Rajasekhar, Lakshmanan Hariprasath, Selvaraj Veerapandian, Gajendran Babu, Nanjian Raaman, Chinnasamy Arulvasu, Sabaratnam Vikineswary, Mycosynthesis and characterization of silver nanoparticles from Pleurotus djamor var. roseus and their in vitro cytotoxicity effect on PC3 cells, Process Biochemistry, 50, 1, 2015. Crossref
-
Pineda-Alegría Jesús Antonio, Sánchez-Vázquez José Ernesto, González-Cortazar Manases, Zamilpa Alejandro, López-Arellano María Eugenia, Cuevas-Padilla Edgar Josúe, Mendoza-de-Gives Pedro, Aguilar-Marcelino Liliana, The Edible MushroomPleurotus djamorProduces Metabolites with Lethal Activity Against the Parasitic NematodeHaemonchus contortus, Journal of Medicinal Food, 20, 12, 2017. Crossref
-
Haque Md. Anwarul, Islam Md. Anwar Ul, Pleurotus highking Mushroom Induces Apoptosis by Altering the Balance of Proapoptotic and Antiapoptotic Genes in Breast Cancer Cells and Inhibits Tumor Sphere Formation, Medicina, 55, 11, 2019. Crossref
-
Chaitanya MVNL, Jose Asha, Ramalingam P, Mandal SC, Kumar PNarendra, Multi-targeting cytotoxic drug leads from mushrooms, Asian Pacific Journal of Tropical Medicine, 12, 12, 2019. Crossref
-
Angelini Paola, Pellegrino Roberto Maria, Tirillini Bruno, Flores Giancarlo Angeles, Alabed Husam B. R., Ianni Federica, Blasi Francesca, Cossignani Lina, Venanzoni Roberto, Orlando Giustino, Menghini Luigi, Ferrante Claudio, Metabolomic Profiling and Biological Activities of Pleurotus columbinus Quél. Cultivated on Different Agri-Food Byproducts, Antibiotics, 10, 10, 2021. Crossref
-
Monticolo Francesco, Chiusano Maria Luisa, Computational Approaches for Cancer-Fighting: From Gene Expression to Functional Foods, Cancers, 13, 16, 2021. Crossref