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International Journal of Medicinal Mushrooms
Главный редактор: Solomon P. Wasser (open in a new tab)

Выходит 12 номеров в год

ISSN Печать: 1521-9437

ISSN Онлайн: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Computational Insights into the Molecular Mechanism of the High Immunomodulatory Activity of LZ-8 Protein Isolated from the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes)

Том 20, Выпуск 6, 2018, pp. 537-548
DOI: 10.1615/IntJMedMushrooms.2018026264
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Краткое описание

Ling zhi-8 (LZ-8) is the first fungal immunomodulatory protein (FIP) isolated from the lingzhi or reishi medicinal mushroom, Ganoderma lucidum. LZ-8 effectively induces interleukin 2 expression and secretion by forming a stable homodimer, and it is regarded as a good candidate to become a new therapeutic agent and/or functional food supplement. However, the molecular mechanism by which LZ-8 dimerization influences the regulation of interleukin 2 is not clear. In this study we performed structure-based multiple alignment of LZ-8 and an FIP from Volvariella volvacea, compared the electrostatic potential of their protein surfaces, and developed a model summarizing the unique electrostatic interaction in LZ-8 dimerization. In addition, further electrostatic potential and virtual amino acid mutation analyses suggested that L10, W12, and D45 are the key amino acid residues responsible for the protein's high immunomodulatory activity. These findings may provide useful insights into the design and construction of a new FIP mutant for use in treating and preventing autoimmune diseases.

ЦИТИРОВАНО В
  1. Wang Ying, Gao Ying Nv, Bai Rui, Chen Hong Yu, Wu Ying Ying, Shang Jun Jun, Bao Da Peng, Identification of a Novel Anti-cancer Protein, FIP-bbo, from Botryobasidium botryosum and Protein Structure Analysis using Molecular Dynamic Simulation, Scientific Reports, 9, 1, 2019. Crossref

  2. Rezvani Vala, Pourianfar Hamid R., Mohammadnejad Safoora, Madjid Ansari Alireza, Farahmand Leila, Anticancer potentiality and mode of action of low-carbohydrate proteins and peptides from mushrooms, Applied Microbiology and Biotechnology, 104, 16, 2020. Crossref

  3. Liu Yusi, Bastiaan-Net Shanna, Wichers Harry J., Current Understanding of the Structure and Function of Fungal Immunomodulatory Proteins, Frontiers in Nutrition, 7, 2020. Crossref

  4. Yadav Divya, Negi Pradeep Singh, Bioactive components of mushrooms: Processing effects and health benefits, Food Research International, 148, 2021. Crossref

  5. Wu Qiang, Li Yong, Peng Kuan, Wang Xiao-Ling, Ding Zhongyang, Liu Liming, Xu Peng, Liu Gao-Qiang, Isolation and Characterization of Three Antihypertension Peptides from the Mycelia of Ganoderma Lucidum (Agaricomycetes), Journal of Agricultural and Food Chemistry, 67, 29, 2019. Crossref

  6. Liu Yusi, Bastiaan-Net Shanna, Zhang Yuebin, Hoppenbrouwers Tamara, Xie Yingying, Wang Yulu, Wei Xue, Du Guoming, Zhang Haowen, Imam Khandader M.D. Sharif Uddin, Wichers Harry, Li Zhen, Linking the thermostability of FIP-nha (Nectria haematococca) to its structural properties, International Journal of Biological Macromolecules, 213, 2022. Crossref

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