Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v2.i2.30
7 pages

Effect of Ganoderma tsugae Murr. (Aphyllophoromycetideae) and Vitamin E Supplementation on Enzyme Activities in the Liver and Plasma of Normal and Chemically Induced Hepatocarcinogenic Rats

Nor Aripin Shamaan
Department of Biochemistry and Microbiology, Universiti Putra Malaysia, 43400 UPM Serdang, Malaysia
Z. Jarien
Department of Biochemistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
B. A. K. Khalid
Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
A. G. M. Top
Division of Chemistry and Technology. Palm Oil Research Institute of Malaysia, Jalan Persiaran llmu, Bandar Baru Bangi. 43600 Bangi, Malaysia
W. Z. Wan Ngah
Department of Biochemistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

Краткое описание

Ganoderma tsugae Murr. and vitamin E (α-tocopherol and γ-tocotrienol) were supplemented, alone and combined, to normal rats and rats chemically induced with cancer using a single injection of diethylnitrosamine followed by 0.2% (w/v) 2-acetylaminofluorene and partial hepatectomy. The rats were treated for 16 weeks before they were killed. The activities of alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γGTP), glutathione S-transferase (GST), and uridyldiphosphate glucuronyltransferase (UDPGT) in plasma and subcellular fractions were determined. Blood glutathione levels were also determined. The activities of γGTP and placental GST were determined histochemically in the liver. The ratio of liver to body weight was significantly increased in the cancer-induced rats compared with normal controls. The ratios were unchanged after G. tsugae and vitamin E supplementation. Blood glutathione levels were significantly higher in the cancer-induced rats than normal controls. Supplementation of G. tsugae and vitamin E lowered blood glutathione levels to normal values. The enzyme activities in the subcellular fractions were higher in the cancer-induced rats than in normal controls. The activities were substantially attenuated upon G. tsugae and vitamin E supplementation. Attenuation of the enzyme-positive foci was also evident upon G. tsugae and vitamin E supplementation in the cancer-induced rats. G. tsugae supplementation that started 3 weeks after cancer induction resulted in a similar effect to G. tsugae supplementation started simultaneously with cancer induction.


Articles with similar content:

Black Hoof Medicinal Mushroom Phellinus linteus (Agaricomycetes) Extracts Protect Against Radiation-Induced Hematopoietic Abnormality in Mice
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 5
Chih-Chung Su, Shu-Ming Huang, Miao-Lin Hu, Jen-Yin Chen, Chin-Chu Chen
Aqueous Extracts of Cordyceps militaris (Ascomycetes) Lower the Levels of Plasma Glucose by Activating the Cholinergic Nerve in Streptozotocin-Induced Diabetic Rats
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 3
Chin-Hsien Chang, Chung-Yuh Tzeng, Yu-Wen Cheng, Hong-Chen Chen, Ying-I Chen, Yiu-Kay Lai, Tai-Hao Hsu, Yu-Chen Lee, Shih-Liang Chang, Chin-Chun Tsai
A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Coronary Heart Disease
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 4
Guoliang Chen, Jingxian Ye, Yihuai Gao, Shufeng Zhou, Xihu Dai
Immunomodulation Effect of Aqueous Extract of the Artist's Conk Medicinal Mushroom, Ganoderma applanatum (Agaricomycetes), on the Rainbow Trout (Oncorhynchus mykiss)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 10
Akram Tehranifard, Mahdi Vazirian, Fereshteh Hassan Zade, Azadeh Manayi
Effect of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. Mycelium on Benzo[a]prene-Induced Early Alterations of the Respiratory Epithelium in the Hypercholesterolaemic Rats
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 2
Suhaila Mohamed, Chow Chin Tong, Nor Aini B. Umar, Mohamed Mustapha Noordin, Yew Keong Choong