Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
Indexed in
Anticancer Effect of Fraction Isolated from Medicinal Birch Polypore Mushroom, Piptoporus betulinus (Bull.: Fr.) P. Karst. (Aphyllophoromycetideae): In Vitro Studies
Краткое описание
Piptoporus betulinus (Bull.: Fr.) P. Karst. (Fomitopsidaceae) has been commonly used in folk medicine as an antiparasitic and antimicrobial agent in the treatment of wounds and for the treatment of rectal cancer and stomach diseases. Tea obtained from this mushroom has antibacterial, antifatiguing, immunoenhancing, and soothing properties. The purpose of the present study was the evaluation of in vitro anticancer activity of fraction isolated from P. betulinus. The effect on cell proliferation, motility, and viability was assessed in a range of cancer and normal cells. P. betulinus fraction prepared from dried fruiting bodies was subjected to anticancer evaluation in human lung carcinoma (A549), colon adenocarcinoma (HT-29), and rat glioma (C6) cell cultures. Human skin fibroblasts (HSF), bovine aorta endothelial cells (BAEC), models of rat oligodenrocytes (OLN-93), hepatocytes (Fao), rat astroglia, and mouse neurons (P19) were applied to test toxicity in normal cells. The following methods were applied: tumor cell proliferation (MTT assay and BrdU assay), cytotoxicity (LDH assay), tumor cell motility (wound assay), tumor cell morphology (May-Grünwald-Giemsa staining), and death detection (ELISA). P. betulinus fraction elicited anticancer effects that were attributed to decreased tumor cell proliferation, motility, and the induction of morphological changes. Of note is the fact that it produced no or low toxicity in tested normal cells.
-
Patel Seema, Goyal Arun, Recent developments in mushrooms as anti-cancer therapeutics: a review, 3 Biotech, 2, 1, 2012. Crossref
-
Grienke Ulrike, Zöll Margit, Peintner Ursula, Rollinger Judith M., European medicinal polypores – A modern view on traditional uses, Journal of Ethnopharmacology, 154, 3, 2014. Crossref
-
Pleszczyńska Małgorzata, Wiater Adrian, Siwulski Marek, Lemieszek Marta K., Kunaszewska Justyna, Kaczor Józef, Rzeski Wojciech, Janusz Grzegorz, Szczodrak Janusz, Cultivation and utility of Piptoporus betulinus fruiting bodies as a source of anticancer agents, World Journal of Microbiology and Biotechnology, 32, 9, 2016. Crossref
-
Doskocil Ivo, Havlik Jaroslav, Verlotta Roberta, Tauchen Jan, Vesela Lucia, Macakova Katerina, Opletal Lubomir, Kokoska Ladislav, Rada Vojtech, In vitroimmunomodulatory activity, cytotoxicity and chemistry of some central European polypores, Pharmaceutical Biology, 54, 11, 2016. Crossref
-
Yang Lixia, Peng Mu, Shah Syed, Wang Qiuyu, Transcriptome Sequencing and Comparative Analysis of Piptoporus betulinus in Response to Birch Sawdust Induction, Forests, 8, 10, 2017. Crossref
-
Pleszczyńska Małgorzata, Lemieszek Marta K., Siwulski Marek, Wiater Adrian, Rzeski Wojciech, Szczodrak Janusz, Fomitopsis betulina (formerly Piptoporus betulinus): the Iceman’s polypore fungus with modern biotechnological potential, World Journal of Microbiology and Biotechnology, 33, 5, 2017. Crossref
-
Jing Yanli, Peng Mu, Yang Lixia, Wang Qiuyu, Evaluation of genetic diversity amongPiptoporus betulinusas revealed by inter simple sequence repeat markers, Biotechnology & Biotechnological Equipment, 31, 2, 2017. Crossref
-
Gründemann Carsten, Reinhardt Jakob K., Lindequist Ulrike, European medicinal mushrooms: Do they have potential for modern medicine? – An update, Phytomedicine, 66, 2020. Crossref
-
Maramokhin E. V, Sirotina M. V, Zontikov D. N, CULTIVATION OF MYCELIUM AND THE STUDY OF THE PHYTOPATHOGENICITY OF CERTAIN XYLOTROPHIC BASIDIOMYCETES UNDER IN VITRO CONDITIONS, Bulletin of Nizhnevartovsk State University, 2, 2020. Crossref
-
Vijayalakshmi S., Karthik K., Winny Fred Crossia A., Subashini G., Bhuvaneswari S., Panneerselvam A., Thatikayala Dayakar, Park Jinsub, Park Mi-Kyung, Fungal secondary metabolites: A potential source of anticancer compounds, in New and Future Developments in Microbial Biotechnology and Bioengineering, 2020. Crossref
-
Dresch Philipp, D´Aguanno Maria Nives, Rosam Katharina, Grienke Ulrike, Rollinger Judith Maria, Peintner Ursula, Fungal strain matters: colony growth and bioactivity of the European medicinal polypores Fomes fomentarius, Fomitopsis pinicola and Piptoporus betulinus , AMB Express, 5, 1, 2015. Crossref
-
Sujata Wangkheirakpam, Devi Sanjram Nomita, Mandal Subhash C., Phytochemicals and Investigations on Traditionally Used Medicinal Mushrooms, in Evidence Based Validation of Traditional Medicines, 2021. Crossref
-
Sułkowska-Ziaja Katarzyna, Fijałkowska Agata, Muszyńska Bożena, Selected Species of Medicinal/Arboreal Mushrooms as a Source of Substances with Antioxidant Properties, in Plant Antioxidants and Health, 2021. Crossref
-
Kour Harpreet, Kour Satwinder, Sharma Yashpal, Singh Shaveta, Sharma Isha, Kour Divjot, Yadav Ajar Nath, Bioprospecting of Industrially Important Mushrooms, in Industrially Important Fungi for Sustainable Development, 2021. Crossref
-
Sułkowska-Ziaja Katarzyna, Fijałkowska Agata, Muszyńska Bożena, Selected Species of Medicinal/Arboreal Mushrooms as a Source of Substances with Antioxidant Properties, in Plant Antioxidants and Health, 2022. Crossref
-
Kityania Sibashish, Nath Rajat, Das Subrata, Nath Deepa, Patra Jayanta Kumar, Talukdar Anupam Das, Fungi as Nutraceutical: Present to Future, in Applied Mycology, 2022. Crossref
-
de Jesus Liana Inara, Smiderle Fhernanda R., Ruthes Andrea C., Vilaplana Francisco, Dal'Lin Fernando Tonholi, Maria-Ferreira Daniele, Werner Maria Fernanda, Van Griensven Leo J.L.D., Iacomini Marcello, Chemical characterization and wound healing property of a β-D-glucan from edible mushroom Piptoporus betulinus, International Journal of Biological Macromolecules, 117, 2018. Crossref
-
Panda Mrunmaya K., Paul Manish, Singdevsachan Sameer K., Tayung Kumananda, Das Swagat K., Thatoi Hrudayanath, Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions, Current Pharmaceutical Biotechnology, 22, 9, 2021. Crossref
-
Marszalek-Grabska Marta, Zakrocka Izabela, Budzynska Barbara, Marciniak Sebastian, Kaszubska Katarzyna, Lemieszek Marta Kinga, Winiarczyk Sylwia, Kotlinska Jolanta H., Rzeski Wojciech, Turski Waldemar A., Binge-like mephedrone treatment induces memory impairment concomitant with brain kynurenic acid reduction in mice, Toxicology and Applied Pharmacology, 454, 2022. Crossref
-
Bożek Justyna, Tomala Joanna, Wójcik Sylwia, Kamińska Beata, Brand Izabella, Pocheć Ewa, Szostak Elżbieta, Effects of Piptoporus betulinus Ethanolic Extract on the Proliferation and Viability of Melanoma Cells and Models of Their Cell Membranes, International Journal of Molecular Sciences, 23, 22, 2022. Crossref