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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v6.i2.50
12 pages

Antimutagenic Activity of Methanolic Extract of Culinary-Medicinal Oyster mushroom, Pleurotus ostreatus (Jacq.:Fr.) Kumm. (strain florida Eger nom. nud.) and Its Protective Effect Against Benzo [a] Pyrene-Induced Hepatic Damages

Bhaskaran Lakshmi
Amala Cancer Research Centre, Kerala, India
Nayana Jose
Amala Cancer Research Centre, Amala Nagar, Thrissur 680 553, Kerala, India
Thekkuttuparambil Ananthanarayanan Ajith
Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur, Kerala, India
Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India

Краткое описание

Oyster mushrooms (Pleurotus species) are excellent culinary-medicinal and commercially cultivated mushrooms. Investigations were carried out to evaluate the antimutagenic activity of the methanolic extract of Pleurotus ostreatus strain florida and its protective effect against Benzo [a] pyrene (B[a]P)-induced hepatic damages. The antimutagenic activity of the extract was assayed by Ames Salmonella mutagenicity test using histidine mutant standard Salmonella typhimurium tester strains, TA98, TA100, and TA102. The extract of the P. ostreatus strain florida significantly reduced (p < 0.001) the in vitro sodium azide (NaN3), N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and 4-nitro-o-phenylene-diamine (NPD), 2-acetamidoflourene (2-AF), and B[a]P-induced his+ revertants in a dose-dependent manner. In vivo antimutagenic activity of extracts was also determined by assaying the mutagenicity of the urine of rat to which B[a]P had been administered as mutagen.The prior administration of P. ostreatus strain florida extract to rat markedly inhibited in vivo mutagenicity caused by B[a]P. The results thus indicated that P. ostreatus strain florida extract possessed significant antimutagenic activity. The status of hepatic transaminases such as serum glutamate oxaloacetate transaminases (SGOT), glutamate pyruvate transaminase (GPT) and alkaline phosphatase activities (ALP) were evaluated in the group of animals treated with B[a]P. Treatment with the extract prevented the increase in SGOT, SGPT, and ALP activities consequent on B[a]P administration. The extract enhanced the levels of reduced glutathione (GSH) and activities of glutathione peroxidase (GPx), glutathione-s-transferase (GST), superoxide dismutase, and catalase (CAT).The extract also showed a profound inhibiting effect on lipid peroxidation induced by B[a]P. The results indicated that the P. ostreatus strain florida extract restored depleted antioxidant defense consequent to the challenge by the carcinogen.


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