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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 22, 2020 Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i4.40
pages 313-320

β-(1→3)-Glucan of the Southern Bracket Mushroom, Ganoderma australe (Agaricomycetes), Stimulates Phagocytosis and Interleukin-6 Production in Mouse Peritoneal Macrophages

Renan Henrique de Melo
Centro de Ciencias Medicas e Farmaceuticas, Universidade Estadual do Oeste do Parana, Cascavel, Parana, Brazil
Alex Evangelista do Amaral
Departamento de Ciencias Farmaceuticas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
Rafael Andrade Menolli
Centro de Ciencias Medicas e Farmaceuticas, Universidade Estadual do Oeste do Parana, Cascavel, Parana, Brazil
Thais Soprani Ayala
Centro de Ciencias Medicas e Farmaceuticas, Universidade Estadual do Oeste do Parana, Cascavel, Parana, Brazil
Rita de Cassia Garcia Simao
Centro de Ciencias Medicas e Farmaceuticas, Universidade Estadual do Oeste do Parana, Cascavel, Parana, Brazil
Arquimedes Paixao de Santana-Filho
Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, Curitiba, Parana, Brazil
Guilherme Lanzi Sassaki
Departamento de Bioquimica e Biologia Molecular, Universidade Federal do Parana, Curitiba, Parana, Brazil
Marina Kimiko Kadowaki
Centro de Ciencias Medicas e Farmaceuticas, Universidade Estadual do Oeste do Parana, Cascavel, Parana, Brazil
Jose Luis da Conceicao Silva
Centro de Ciencias Medicas e Farmaceuticas, Universidade Estadual do Oeste do Parana, Cascavel, Parana, Brazil

Краткое описание

Ganoderma australe was studied to determine the composition of the cell wall, and polysaccharide fraction SK5 was obtained after freeze-thawing an aqueous 5% potassium hydroxide extraction. The monosaccharide composition of the SK5 fraction revealed by gas chromatography−mass spectrometry showed 81.3% glucose, and analyses by 13C nuclear magnetic resonance spectroscopy confirmed a β-glucan with glycosidic links of the (1→3)-β type and most likely 4-O substituted. In addition, the biological effect of the β-glucan from G. australe was evaluated via in vitro cell cultures of peritoneal macrophages isolated from Swiss mice. Biological assays were assessed for toxicity and cell activation, interleukin-6 cytokine concentrations, and the ability to stimulate phagocytic activity. There was an increase in interleukin-6 by approximately 111% with 1.0 µg/mL of polysaccharide, and phagocyte activity was increased in all concentrations examined, obtaining 52.3% with 0.25 µg/mL polysaccharide. The results indicate that a β-(1→3)-glucan isolated from G. australe can be classified as a biological response modifier.


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