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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024492
pages 767-775

In Vitro and In Vivo Antitumoral Activity of Exobiopolymers from the Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes)

Vanessa Sovrani
Department of Biochemistry and Molecular Biology, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
Juliana da Rosa
Department of Biology, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil
Mariana de Paula Drewinski
Department of Biology, Universidade Federal de Santa Catarina, Florianopólis, Santa Catarina, Brazil
Franciely Grose Colodi
Department of Biochemistry and Molecular Biology, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
Tânia Toyomi Tominaga
Department of Physics, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil
Herta Stutz Dalla Santa
Bioprocess Engineering and Biotechnology Division, Federal University of Paraná, Curitiba, Paraná, Brazil
Rosilene Rebeca
Department of Biology, Universidade Estadual do Centro-Oeste, Guarapuava, Paraná, Brazil

Краткое описание

We studied antitumor activity in vitro and in vivo and partial chemical characterization of exobiopolymers (EBPs) of Agaricus brasiliensis produced by submerged cultivation. The EBPs comprised 61.2% total sugar and 22.3% total protein, and the chromatographic profile mainly identified mannose (65.5%), galactose (17.5%), and glucose (13.1%). In vitro analysis revealed a dose with antitumor effectiveness, time-dependent treatment, and 46% inhibition of solid Walker 256 tumors in rats. Metabolic changes were significant in the spleens of the animals; this is possibly related to higher immune activity triggered by the presence of EBPs in the treated group. The increase of nitric oxide production by peritoneal macrophages from animals may be related to the tumor reduction observed, because nitric oxide acts as an important effector pathway in the defense of the organism.


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