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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v10.i1.60
pages 49-53

In Vitro Anti-inflammatory Activity of Selected Japanese Higher Basidiomycetes Mushrooms

Esameldin E. Elgorashi
Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, 4-101 Minami, Koyama, Tottori 680-8553, Japan
Nitaro Maekawa
The Tottori Mycological Institute, Kokoge 211, Tottori-shi, Tottori 689-1125, Japan
Hiroshi Satoh
Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, 4-101 Minami, Koyama, Tottori 680-8553, Japan

Краткое описание

Mycelial extracts (ethyl acetate and 70% ethanol) of 20 higher Basidiomycetes edible or medicinal mushrooms and culture media extracts (ethyl acetate and Butan-1-ol) were evaluated for in vitro anti-inflammatory activity using the cyclooxygenase-1 and -2 enzymes (COX-1 and -2). Generally, 70% ethanolic extracts showed lower inhibitory activity against both enzymes compared to ethyl acetate extracts. Of the mushrooms tested, the ethyl acetate extracts of Ganoderma applanata, Naematoloma sublateritium, Pleurotus eryngii, and P. salmoneostramineus showed the highest COX-2 inhibitory effects (IC50 values of 49.7, 80.6, 121.7, and 115.8 μg/mL, respectively) compared to COX-1 inhibition (IC50 values of 125.3, 156, 188.9, and 250 μg/mL, respectively). Of the culture media tested in this study, only the ethyl acetate extracts of the culture medium of Agrocybe cylindracea exhibited high inhibition of the COX-2 enzyme.


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