Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
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Evaluation of the Antigenotoxic Effects of the Royal Sun Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) in Human Lymphocytes Treated with Thymol in the Comet Assay
Краткое описание
The aim of this investigation was to evaluate the possible protective activity of Agaricus brasiliensis (=A. blazei sensu Murrill) ethanol extract against thymol-induced DNA damage in human lymphocytes. Before we studied the possible interaction of thymol and A. brasiliensis extract, each component was tested in the comet assay. Thymol significantly increased DNA damage in human lymphocytes at higher concentrations (20, 50, 100, 150, and 200 µg/mL), whereas no genotoxic effect of A. brasiliensis ethanol extract was observed. In simultaneous treatment with thymol (200 µg/mL) and A. brasiliensis ethanol extract (50, 100, 150, and 200 µg/mL), the latter failed to reduce a thymol-induced DNA damaging effect regardless of the applied concentrations. To confirm that thymol induces DNA damage via reactive oxygen species, we performed cotreatment with quercetin. Cotreatment with quercetin (100 and 500 µmol/L) significantly reduced DNA damage caused by thymol (200 µg/mL), indicating that thymol exhibits genotoxicity mainly through induction of reactive oxygen species.
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Živković Lada, Borozan Sunčica, Čabarkapa Andrea, Topalović Dijana, Ciptasari Ummi, Bajić Vladan, Spremo-Potparević Biljana, Antigenotoxic Properties ofAgaricus blazeiagainst Hydrogen Peroxide in Human Peripheral Blood Cells, Oxidative Medicine and Cellular Longevity, 2017, 2017. Crossref
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Geyikoglu Fatime, Cerig Salim, Ozdal Murat, Koc Kubra, Algur Omer Faruk, Yildiz Gulsah Deniz, Gulmez Ozlem, Toxicological evaluation of submerged liquid culture from Phanerochaete chrysosporium mycelium on human blood cells: cytotoxicity, genotoxicity and oxidative damage, International Journal of Secondary Metabolite, 2017. Crossref
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EMSEN Buğrahan, GÜVEN Büşranur, KAYA Abdullah, Yabani Yenilebilir Bir Mantar Olan Lycoperdon molle Pers.'nin Antioksidan ve Antigenotoksik Potansiyeli, Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 22, 5, 2019. Crossref
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Rajkovic Milan, Stanimirovic Zoran, Stevanovic Jevrosima, Ristanic Marko, Vejnovic Branislav, Goblirsch Michael, Glavinic Uros, Evaluation of genotoxic and genoprotective effects of Agaricus bisporus extract on AmE-711 honey bee cell line in the Comet assay, Journal of Apicultural Research, 2022. Crossref