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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/InterJMedicMush.v5.i3.30
14 pages

Structure and Antitumor Activity of 1,3-b-Glucan from Cultivated Fruit Bodies of Culinary–Medicinal Mushroom Hypsizygus marmoreus (Peck) Bigel. (Agaricomycetideae)

Masuro Motoi
Toei Pharmaceutical Co. Ltd., 2-5-3 Iguchi, Mitaka, Tokyo 181-0011; Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan
Shigeyuki Goto
Gotogumi Co. Ltd., Yonezawa, Yamagata Japan
Naohito Ohno
Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo, Japan

Краткое описание

Hypsizygus marmoreus is an edible mushroom widely cultured in Japan. Polysaccharide fractions were prepared from the cultured H. marmoreus by repeated extraction with hot water (HmHWE), cold NaOH, and then hot NaOH. The residue was further treated with NaClO and prepared extract (HmCHAE) and residue (HmCHAR). The cold NaOH extract was further separated into water-soluble (HmCAEE) and -insoluble (HmCAER) fractions. The hot NaOH extract was also separated into water-soluble (HmHAEE) and -insoluble (HmHAER) fractions. Cold and hot NaOH extracts showed antitumor activity to the solid form of Sarcoma 180 in ICR mice. By chemical, enzymic, and NMR analyses, HmCAEE and HmHAEE contained significant amounts of 6-branched 1,3-b-glucan. In addition to 6-branched 1,3-b-glucan, NaOH extracted, water-insoluble fraction contained 1,3-a-glucan. Purified 1,3-a-glucan did not show antitumor activity. These facts strongly suggested that b-glucans but not a-glucans show antitumor activity in H. marmoreus.


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