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International Journal of Medicinal Mushrooms
Главный редактор: Solomon P. Wasser (open in a new tab)

Выходит 12 номеров в год

ISSN Печать: 1521-9437

ISSN Онлайн: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Effects of a Hot-Water Extract of Trametes versicolor (L.: Fr.) Lloyd (Aphyllophoromycetideae) on the Recovery of Rat Liver Function

Том 2, Выпуск 1, 2000, 7 pages
DOI: 10.1615/IntJMedMushr.v2.i1.30
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Краткое описание

To investigate influences of Trametes versicolor on hepatocarcinoma and regenerated normal hepatocytes, hot-water extract (CVA) and ethanol-soluble (CVB) and ethanol-insoluble (CVC) fractions of its basidiocarps were examined for growth inhibition of hepatoma cells and primary culture of hepatocytes isolated from regenerated rat liver at 24 h after partial hepatectomy were studied for effects on DNA, RNA, protein, and collagen biosynthesis. Fractions CVA, CVB, and CVC inhibited the growth of the SK-Hep-1 cell line at a concentration of 100 μg/ml. The 50% inhibitory concentrations (IC50) of CVA, CVB, and CVC fractions against SK-Hep-1 were 36.9, 64.2, and 37.1 μg/ml, respectively. In DNA biosynthesis ability that was measured by incorporation of [3H]thymidine in the primary cultured hepatocytes, fractions CVA and CVC augmented DNA biosynthesis by 1.5- and 1.4-fold of that of the control, respectively. Fractions CVA and CVC also increased RNA biosynthesis ability to 1.5- and 1.8-fold of that of the control, respectively. Fractions CVA and CVC potentiated protein biosynthesis ability to 1.4- and 1.5-fold to that of the control, respectively. Stimulatory effects of both CVA and CVC fractions on collagen biosynthesis were 1.2-fold of that of the control, respectively. In summary, it was found that all three fractions significantly inhibited human hepatoma cell growth in vitro at a concentration of 100 μg/ml and fractions CVA and CVC significantly restored the function of the regenerated hepatocytes. Therefore, the high molecular weight fraction, CVC, showed inhibitory action on the hepatoma cell and stimulatory or recovery functions of normal hepatocytes. Therefore the high molecular weight fraction of T. versicolor has the potential to be developed as a hepatoprotective agent.

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