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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018028595
pages 1047-1063

Overview of the Biological Activities of a Methanol Extract from Wild Red Belt Conk, Fomitopsis pinicola (Agaricomycetes), Fruiting Bodies from Central Italy

Paola Angelini
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
Bruno Tirillini
Department of Biomolecular Sciences, University of Urbino, Urbino, Italy
Giancarlo Bistocchi
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
Andrea Arcangeli
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
Andrea Rubini
National Research Council, Institute of Biosciences and Bioresources, Perugia, Italy
Roberto Maria Pellegrino
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
Roberto Fabiani
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
Gabriele Cruciani
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
Roberto Venanzoni
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy
Patrizia Rosignoli
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy

Краткое описание

Fomitopsis pinicola (Sw.) P. Karst. (Fomitopsidaceae) is a medicinal mushroom with a variety of healthy properties. In this study we tested the radical scavenging activity and antimicrobial and anticancer potential of methanol extracts of F. pinicola from central Italy. Molecular identification confirmed that the samples were F. pinicola; a Basic Local Alignment Search Tool search showed a close match (99% sequence identity) with European isolates of this species. The free radical scavenging capacities, measured by DPPH assay, showed that the extract activity was 3.5% that of Trolox. The MTT test, evaluated after 72 hours of treatment with increasing doses of extract (5-500 μg · mL-1), considerably inhibited proliferation in a dose-dependent manner in 2 human tumor cell lines. This reduction was coupled with a relevant induction of apoptosis in the human leukemia THP-1 cell line after 24 hours of treatment, but a relevant toxic effect occurred in the human colon adenocarcinoma HT29 cell line. The genotoxic potential of the methanol extracts was studied by single-cell gel electrophoresis of normal human leukocytes exposed to 20 μg extract at 37°C for 30 minutes; no DNA damage was observed. The F. pinicola methanol extract was found to have varying degrees of antifungal effects against the pathogenic fungi tested (minimum inhibitory concentration from 23.63 to 66.81 μg · mL-1). The results show that the tested F. pinicola extract has strong antimicrobial and chemo-preventive activities, but is a poor antioxidant.


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