RT Journal Article
ID 16155cc408ab10e8
A1 Lachter, Jesse
A1 Yampolsky, Yevgeny 
A1 Gafni-Schieber, Ronit 
A1 Wasser, Solomon P.
T1 Yellow Brain Culinary-Medicinal Mushroom, <i>Tremella mesenterica</i> Ritz.:Fr. (Higher Basidiomycetes), is Subjectively but not Objectively Effective for Eradication of <i>Helicobacter pylori</i>: A Prospective Controlled Trial
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2012
FD 2012-02-10
VO 14
IS 1
SP 55
OP 63
K1 medicinal mushrooms
K1 <i>Tremella mesenterica
K1 Helicobacter pylori</i>
K1 alternative medicine
AB Inhibitory effects of the higher Basidiomycetes mushrooms, including species of genus <i>Tremella</i>, on the growth of <i>Helicobacter pyroli</i> (Hp) have been described. This study aimed to test <i>T. mesenterica</i> (Tm) efficacy <i>in vivo</i> on eradication of Hp. This IRB-approved study included 52 consenting patients diagnosed with Hp infections. The patients were selected for 10-day treatments with one of the three arms of the protocol, namely, (i) Tm 2 g, (ii) Tm given with omeprazole 20 mg, or (iii) omeprazole 20 mg, clarithromycin 500 mg, and amoxicillin 1000 mg (all regimens given twice daily). The Tm submerged cultivated mycelium in the form of tablets (1 g) was supplied free of charge to patients. Three weeks after completing the therapy, breath testing was assessed for Hp eradication. The patients who took the standard triple therapy had a 70&#37; (n &#61; 14) eradication rate of Hp. Of the patients taking Tm, with and without omeprazole, only one had a breath test indicative of eradication of Hp,<i> p</i> &#60; 0.000. Tm-treated patients had fewer adverse events and equivalent symptomatic relief. Limitations of this study include the brief duration of Tm therapy. Longer treatment might achieve better results, but was judged to be not warranted, so as to not excessively further delay accepted therapy. Ten-day Tm was not found to be effective <i>in vivo</i> in eradicating Hp, whether if given with or without omeprazole. Significant symptomatic relief found among Tm-treated patients suggests that further study of Tm is well justified.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,6ea99e900554f74c,16155cc408ab10e8.html