RT Journal Article ID 17b7de32065e6faf A1 Sharma, Samta A1 Raghuvanshi, Suchita A1 Jaswal, Amita A1 Shrivastava, Sadhana A1 Shukla, Sangeeta T1 Lead Acetate-Induced Hepatoxicity in Wistar Rats: Possible Protective Role of Combination Therapy JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2015 FD 2015-02-27 VO 34 IS 1 SP 23 OP 34 K1 lead K1 N-acetyl cysteine K1 selenium K1 DNA damage AB Experimental studies have shown that sulphur-containing antioxidants have beneficial effects against the detrimental properties of Pb. In the present study, we investigated the therapeutic potential of combined administration of N-acetyl cysteine (NAC; 50 mg/kg p.o.) and selenium (Se; 0.5 mg/kg p.o.) against lead acetate intoxication (Pb; 0.2% in water ad libitum) in a male rat model for 12 wk. The exposure of rats to lead acetate produced significant (P < 0.05) alterations in cytochrome P450 (CYP) activity, microsomal lipid peroxidation, reduced glutathione, and proteins. In addition, significant elevation in liver markers transaminases, triglycerides, cholesterol, and bilirubin as well as a decline in albumin were also compared with the experimental control rats. Combined treatment of lead-exposed animals with NAC and Se showed marked improvement of the biochemical, molecular, and histopathological findings. These experimental results strongly indicate the protective effect of NAC alone with Se against toxic effects of lead on liver tissue. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,455443d31df03fbb,17b7de32065e6faf.html