RT Journal Article ID 1eb18b8402037409 A1 Hamidi, Mehrdad A1 Foroozesh, Mahshid A1 Zarrin, Abdolhossein T1 Lipoproteins: From Physiological Roles to Drug Delivery Potentials JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2006 FD 2007-04-05 VO 23 IS 6 SP 497 OP 523 AB Lipoproteins, the endogenous lipid-protein associations responsible for lipid metabolism within the human body, have attracted interest in recent years for their potential as drug delivery carriers owing to, mainly, their lipophilic/amphiphilic nature, which makes them ideal for interacting with highly lipophilic drugs. After lipoprotein particles have been isolated from the blood, drugs can be "loaded" onto them with a variety of methods. Loading can be done either in soluble/suspended form in a liquid medium or as a dry film. Each method has advantages and disadvantages. The drug-loaded lipoproteins can be modified by the attachment of different ligands that target the particles to specific tissue/cell types within the body. A wide variety of drug molecules both from small molecular or macromolecular structures have been tested successfully, mostly in vitro, for their potential for delivery by lipoprotein carriers. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,7c4e307b0c90da88,1eb18b8402037409.html