%0 Journal Article %A Sitnicka, Ewa %D 2009 %I Begell House %K lineage commitment, hematopoietic progenitors, hematopoietic growth factors, transcription factors, deficiencies, leukemia %N 6 %P 487-530 %R 10.1615/CritRevImmunol.v29.i6.30 %T From the Bone Marrow to the Thymus: The Road Map of Early Stages of T-Cell Development %U https://www.dl.begellhouse.com/journals/2ff21abf44b19838,0e9e83c77713325b,262881fd6b2a000f.html %V 29 %X The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the HSCs in the bone marrow to the lineage committed T cells inside the thymus. %8 2010-02-02