RT Journal Article ID 32760ecd0f46420b A1 Amoako-Tuffour, Yaw A1 Jones, Mitchell L. A1 Shalabi, Nabil A1 Labbe, Alain A1 Vengallatore, Srikar A1 Prakash, Satya T1 Ingestible Gastrointestinal Sampling Devices: State-of-the-Art and Future Directions JF Critical Reviews™ in Biomedical Engineering JO CRB YR 2014 FD 2014-08-15 VO 42 IS 1 SP 1 OP 15 K1 Autonomous ingestible device K1 electromechanical capsule K1 luminal intestinal content collection AB Despite the significant contribution of gastrointestinal diseases to the global disease burden and the increasing recognition of the role played by the intestinal microbiota in human health and disease states, conventional methods of exploring and collecting samples from the gastrointestinal tract remain invasive, resource intensive, and often unable to capture all the information contained in these heterogeneous samples. A new class of gastrointestinal sampling capsules is emerging in the literature, which contains the components required for an autonomous intra-luminal device and preserves the spatial and temporal information of the gastrointestinal samples. In this paper, we identify the primary design requirements for gastrointestinal sampling capsules, and we review the state-of-the-art for different components and functionalities. We also suggest two design concepts, and we highlight future directions for this class of biomedical devices. PB Begell House LK https://www.dl.begellhouse.com/journals/4b27cbfc562e21b8,5d2385320a8fec1d,32760ecd0f46420b.html