RT Journal Article ID 3939a6a52982c13b A1 Speck, Nancy A. A1 Stacy, Terryl T1 A New Transcription Factor Family Associated with Human Leukemias JF Critical Reviews™ in Eukaryotic Gene Expression JO CRE YR 1995 FD 1995-12-20 VO 5 IS 3-4 SP 337 OP 364 K1 CBF K1 PEBP2 K1 AML1 K1 CBFB K1 t(8;21) K1 t(3;21) K1 t(12;21) K1 inv(16). AB The proteins known as the polyoma enhancer binding protein 2 or core-binding factor (PEBP2/CBF) are heterodimeric transcription factors that contain a DNA-binding subunit (CBFα), and a subunit that does not bind DNA independently (CBFβ). PEBP2 and CBF were identified independently as proteins that regulate transcription of viral and cellular enhancers, and also as proteins whose genes are disrupted by chromosomal abnormalities in human leukemias. This review traces the history of the discovery of the PEBP2 and CBF protein family and describes the biochemical properties of the normal and oncogenic forms of these proteins. PB Begell House LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,1bf924415e55094a,3939a6a52982c13b.html