RT Journal Article
ID 4a25181f69623f98
A1 Veena, Ravindran Kalathil
A1 Ajith, Thekkuttuparambil Ananthanarayanan
A1 Janardhanan, Kainoor Krishnankutty
T1 Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Prevents Doxorubicin-Induced Cardiotoxicity in Rats
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2018
FD 2018-08-17
VO 20
IS 8
SP 761
OP 774
K1 antioxidants
K1 cardiotoxicity
K1 doxorubicin
K1 free radicals
K1 Ganoderma lucidum
K1 medicinal mushrooms
AB Doxorubicin (DOX) is an anticancer drug used extensively to treat a variety of human malignancies. DOX chemotherapy often leads to serious cardiotoxicity. We examined the ability of a Ganoderma lucidum extract (GLE) to prevent DOX-associated cardiotoxicity. DOX treatment of cardiac tissue drastically increased levels of creatine kinase (CK), lactate dehydrogenase (LDH), lipid peroxidation (thiobarbituric acid-reactive substances), advanced oxidation protein products (AOPPs), and protein carbonyls (PCOs), and significantly decreased reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activities. Administration of GLE restored CK, LDH, AOPPs, and PCOs to almost normal levels and significantly enhanced the activity of SOD, GPx, catalase, and GSH; it also downregulated lipid peroxidation. Histopathological observations, hematology profiles, and electrocardiography parameters supported the protective effect of GLE against cardiotoxicity associated with DOX treatment.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,66746bdc1bb430f2,4a25181f69623f98.html