RT Journal Article ID 4a25181f69623f98 A1 Veena, Ravindran Kalathil A1 Ajith, Thekkuttuparambil Ananthanarayanan A1 Janardhanan, Kainoor Krishnankutty T1 Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Prevents Doxorubicin-Induced Cardiotoxicity in Rats JF International Journal of Medicinal Mushrooms JO IJM YR 2018 FD 2018-08-17 VO 20 IS 8 SP 761 OP 774 K1 antioxidants K1 cardiotoxicity K1 doxorubicin K1 free radicals K1 Ganoderma lucidum K1 medicinal mushrooms AB Doxorubicin (DOX) is an anticancer drug used extensively to treat a variety of human malignancies. DOX chemotherapy often leads to serious cardiotoxicity. We examined the ability of a Ganoderma lucidum extract (GLE) to prevent DOX-associated cardiotoxicity. DOX treatment of cardiac tissue drastically increased levels of creatine kinase (CK), lactate dehydrogenase (LDH), lipid peroxidation (thiobarbituric acid-reactive substances), advanced oxidation protein products (AOPPs), and protein carbonyls (PCOs), and significantly decreased reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activities. Administration of GLE restored CK, LDH, AOPPs, and PCOs to almost normal levels and significantly enhanced the activity of SOD, GPx, catalase, and GSH; it also downregulated lipid peroxidation. Histopathological observations, hematology profiles, and electrocardiography parameters supported the protective effect of GLE against cardiotoxicity associated with DOX treatment. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,66746bdc1bb430f2,4a25181f69623f98.html