RT Journal Article
ID 4c900f42395a323b
A1 Rossetti, Maura
A1 Spreafico, Roberto 
T1 Regulatory T-Cell Therapy in Transplantation and Severe Autoimmunity
JF Critical Reviews™ in Immunology
JO CRI
YR 2015
FD 2016-04-18
VO 35
IS 6
SP 479
OP 503
K1 Treg cells
K1 FOXP3
K1 immune tolerance
K1 low-dose IL-2
K1 GvHD
AB Current approaches to prevent or treat transplant rejection, graft-versus-host disease and severe autoimmunity rely on non-specific immunosuppressive drugs. Ongoing efforts aimed at harnessing regulatory T (Treg) cells hold promise for revolutionizing the current therapeutic options, reducing if not abandoning immune suppression in favor of immune tolerance. This paradigm shift carries the potential of dramatically enhancing efficacy, persistency, and specificity while reducing side effects. Here, we review the various strategies devised to manipulate Treg cells <i>in vitro</i> and <i>in vivo</i>, the clinical progress achieved to date, and critical issues that still need to be addressed.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,1d0a61632cf916bf,4c900f42395a323b.html