RT Journal Article
ID 598faaed030c0bf7
A1 Kupcova, Kristyna 
A1 Stefanova, Iveta 
A1 Plavcova, Zuzana 
A1 Hosek, Jan 
A1 Hrouzek, Pavel 
A1 Kubec, Roman
T1 Antimicrobial, Cytotoxic, Anti-Inflammatory, and Antioxidant Activity of Culinary Processed Shiitake Medicinal Mushroom (<i>Lentinus edodes</i>, Agaricomycetes) and Its Major Sulfur Sensory-Active Compound&minus;Lenthionine
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2018
FD 2018-04-04
VO 20
IS 2
SP 165
OP 175
K1 anti-inflammatory activity
K1 antimicrobial activity
K1 antioxidant activity
K1 cytotoxic activity
K1 lenthionine
K1 <i>Lentinus edodes</i>
K1 medicinal mushrooms
K1 shiitake
AB The antimicrobial, cytotoxic, anti-inflammatory, and antioxidant properties of aqueous extracts of raw and culinary processed shiitake mushrooms were evaluated and compared with those of lenthionine (1,2,3,5,6-penta-thiepane), the principal aroma-bearing substance of the shiitake medicinal mushroom (<i>Lentinus edodes</i>). Antimicrobial activity was tested using a panel of 4 strains of bacteria, 2 yeasts, and 2 fungi. Cytotoxic properties were evaluated against 3 cell lines (HepG2, HeLa, PaTu), whereas the anti-inflammatory activity of tested samples was assayed based on their ability to attenuate the secretion of the cytokine tumor necrosis factor-&alpha;. Antioxidant activity was measured using <i>in vitro</i> DPPH and ABTS assays. It was found that lenthionine possesses significant antimicrobial properties; it is remarkably effective in inhibiting the growth of yeasts and fungi (minimum inhibitory concentration, 2-8 &mu;g/mL) and thus is comparable to standard antifungal agents. Lenthionine is also able to decrease significantly the production of tumor necrosis factor-a and thus could be at least partly responsible for the observed anti-inflammatory effect of shiitake. On the other hand, lenthionine does not seem to contribute significantly to the well-known anticancer and antioxidant effects of the mushroom.


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