RT Journal Article
ID 5e60d86768b7ebcc
A1 Rana, Tanmoy
A1 Bera, Asit Kumar
A1 Bhattacharya, Debasis
A1 Das, Subhashree
A1 Pan, Diganta
A1 Das, Subrata Kumar
T1 Evidence of Antiapoptotic Properties of Pleurotus florida Lectin Against Chronic Arsenic Toxicity in Renal Cells of Rats
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2012
FD 2012-05-10
VO 31
IS 1
SP 39
OP 48
K1 arsenic
K1 Pleurotus florida lectin
K1 apoptosis
K1 renal cells
AB Chronic arsenic exposure results in toxicity in humans and causes many toxicologic manifestations. Apoptosis was measured by cell adhesion, morphologic alterations, cell proliferation, terminal deoxyuridine triphosphate nick-end labeling (TUNEL), and caspase-3/CPP32 fluorometric protease assay. Results of the present study suggested that arsenic administration in rats caused apoptosis by elevating morphologic alterations, TUNEL-positive nuclei, caspase-3 activity, and DNA damage and by reducing cell adhesion and cell proliferation in a time-dependent manner. The apoptosis in renal cells of arsenic-exposed rats reverted to normal values after coadministration of mushroom lectin. This study provided significant evidence that Pleurotus florida lectin has an antiapoptotic property by protecting from arsenic-induced toxicity. The beneficial effect of Pleurotus florida lectin was proportional to its duration of exposure. This finding might be of therapeutic benefit in people suffering from chronic exposure to arsenic from natural sources, a global problem that is especially relevant to millions of people on the Indian subcontinent
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,61606000215a4666,5e60d86768b7ebcc.html