RT Journal Article ID 66f774b5694a4074 A1 Bonavida, Benjamin A1 Huerta-Yepez, Sara A1 Baritaki, Stavroula A1 Vega, Mario I. A1 Liu, H. A1 Chen, Haiming A1 Berenson, James R. T1 Overexpression of Yin Yang 1 in the Pathogenesis of Human Hematopoietic Malignancies JF Critical Reviews™ in Oncogenesis JO CRO YR 2011 FD 2012-01-03 VO 16 IS 3-4 SP 261 OP 267 K1 non-Hodgkin lymphoma K1 AIDS-related lymphoma K1 multiple myeloma K1 chronic lymphocytic leukemia K1 Yin Yang 1 prognostic factor AB The transcription factor Yin Yang (YY) 1 has been reported to be overexpressed in several tumor types and plays a role in both the progression of the disease as well as the maintenance of tumor cell resistance to cell death by cytotoxic drugs. YY1 also has been reported to be a prognostic factor for several cancers and was proposed to be a therapeutic target. The expression, function, and role of YY1 in the pathogenesis of hematologic malignancies are summarized briefly herein. Data are represented for B non-Hodgkin lymphoma, AIDS-related lymphoma, multiple myeloma, and children’s acute lymphocytic leukemia. PB Begell House LK https://www.dl.begellhouse.com/journals/439f422d0783386a,0cf292416bbaa73d,66f774b5694a4074.html