RT Journal Article ID 6e27e37a4746cf3b A1 Chaudhary, Ranu A1 Jahan, Swafiya A1 Goyal, Pradeep Kumar T1 Chemopreventive Potential of an Indian Medicinal Plant (Tinospora cordifolia) on Skin Carcinogenesis in Mice JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2008 FD 2008-07-22 VO 27 IS 3 SP 233 OP 243 AB Tinospora cordifolia (Guduchi), an Indian medicinal plant, was used to explore antitumor promoting activity in a two-stage skin carcinogenesis model. For this purpose, mice were treated by single application of DMBA (100 μg/100 μl of acetone) and two weeks later promoted by croton oil (1% in acetone three times a week) until the end of the experiment (i.e., 16 weeks). Oral administration of the above extract at the preinitiational stage (i.e., seven days before and seven days after DMBA application; group IV), promotional stage (i.e., from the time of croton oil application; group V), and both pre- and postintiational stage (i.e., from the time of DMBA application and continued until the end of the experiment; group VI; on the shaven backs of the mice at the dose of 100 mg/kg body weight/day for 16 weeks) recorded significant reduction in tumor weight, tumor incidence in comparison to control (i.e., mice treated with DMBA and croton oil; group III). Furthermore, cumulative number of papillomas, tumor yield, tumor burden, and tumor weight showed significant reduction along with significant elevation of phase II detoxifying enzymes, and inhibition of lipid peroxidation in liver and skin in the animals administered with such plant extract concomitant to carcinogen exposure. Thus, the present data strongly suggests that the Tinospora cordifolia extract has anti-tumor potential in a two-stage skin carcinogenesis mouse model. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,4197f439193f0808,6e27e37a4746cf3b.html