RT Journal Article
ID 78dcdae330b90c76
A1 Reed, Elaine F.
T1 Signal Transduction via MHC Class I Molecules in Endothelial and Smooth Muscle Cells
JF Critical Reviews™ in Immunology
JO CRI
YR 2003
FD 2003-04-01
VO 23
IS 1-2
OP 20
AB MHC class I molecules have long been recognized for their ability to stimulate intracellular signals in T and B lymphocytes. More recently, it has become clear that MHC class I molecules can also initiate intracellular signals in endothelial and smooth muscle cells, which synergize with growth factor receptors to elicit cell proliferation. This review describes our current knowledge of class I–mediated signaling pathways in human endothelial and smooth muscle cells. The role of the class I signaling pathway in modulating cell growth and the clinical significance of this pathway in chronic allograft rejection are discussed.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,3866ada64de76cc9,78dcdae330b90c76.html