Доступ предоставлен для: Guest
Critical Reviews™ in Immunology
Anahid Jewett (open in a new tab) Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, 90095 Los Angeles, CA, USA; The Jonsson Comprehensive Cancer Center, UCLA School of Dentistry and Medicine, Los Angeles, CA, USA
Geraldo Aleixo Passos (open in a new tab) Molecular Immunogenetics Group, University of São Paulo, Ribeirão Preto Campus, São Paulo, Brazil
Malarkannan Subramaniam (open in a new tab) Nan Gardetto Endowed Chair for Immunotherapy Senior Investigator Versiti Blood Research Institute. Professor Department of Medicine-Hematology and Oncology, Department of Microbiology and Immunology, Department of Pediatrics-Hematology, Oncology, and Transplantation, Center for Immunology, Cancer Center of Southeastern Wisconsin, Clinical and Translational Science Institute, The Medical College of Wisconsin, Milwaukee, WI-53226; Principal Investigator, Laboratory of Immunotherapy, Versiti BRI.
Bergithe E. Oftedal (open in a new tab) Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway
Xiaolei Tang (open in a new tab) Associate Professor, Physiology and Immunology Department of Biomedical Sciences College of Veterinary Medicine, Long Island University 720 Northern Blvd., Room 210, Roth Hall, Brookville, NY 11548-1327
Kawaljit Kaur (open in a new tab) Division of Oral Biology and Medicine The Jane and Jerry Weintraub Center of Reconstructive Biotechnology University of California School of Dentistry Los Angeles, CA, USA
M. Zouhair Atassi (open in a new tab) Baylor College of Medicine, Houston, TX 77030, USA
The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Emerging Sources Citation Index (ESCI) Clarivate SCIE BOISIS (Clarivate) Scopus EMBASE (Elsevier) Chemical Abstracts Service EBSCO PubMed British Library Google Scholar Ulrich's CNKI Portico Copyright Clearance Center iThenticate Scientific Literature

Novel Coronavirus SARS-CoV-2 Target and Disable Natural Killer Cells: Core Immune Effectors for Fighting the Disease

pages 167-171
DOI: 10.1615/CritRevImmunol.2020034441
Get accessGet access

Краткое описание

Coronavirus disease 2019 (COVID-19) poses a great public health challenge worldwide. While studies on the effects of SARS-CoV-2 on immune cell function continue to progress, we know very little about the significance of depletion of key immune effectors by the virus in the mortality and morbidity of the disease. This commentary reviews what is known thus far about the effects of the virus on natural killer (NK) cells, the major cell type responsible for the destruction and removal of virally infected cells. It also highlights the necessity of comprehensive studies of NK cells in COVID-19 patients and animal models to better understand the role and significance of reported NK depletion and functional inactivation in disease morbidity and mortality, in the hopes of designing effective therapeutic interventions for the disease.

Ключевые слова: natural killer cells, coronavirus, COVID-19, SARS-CoV-2
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain